Evidence map›Paper›PMID 40598979›Full record

ArticleAustralian endodontic journal : the journal of the Australian Society of Endodontology Inc2025

Correlation Between LPS and LTA Levels With Clinical Features in Secondary Endodontic Infections.

Ederaldo P Godoi, Pedro Ivo G Fagundes, Priscila A Francisco, Maraísa G Delboni, Marlos Barbosa-Ribeiro, Marcos S Endo, Erica M Lopes, Frederico C Martinho, Brenda P F A Gomes

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Article in Australian endodontic journal : the journal of the Australian Society of Endodontology Inc, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ederaldo P GodoiDepartment of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, State University of Campinas-UNICAMP, Piracicaba, SP, Brazil.
Pedro Ivo G FagundesDepartment of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, State University of Campinas-UNICAMP, Piracicaba, SP, Brazil.
Priscila A FranciscoDepartment of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, State University of Campinas-UNICAMP, Piracicaba, SP, Brazil.
Maraísa G DelboniDepartment of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, State University of Campinas-UNICAMP, Piracicaba, SP, Brazil.
Marlos Barbosa-RibeiroDepartment of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, State University of Campinas-UNICAMP, Piracicaba, SP, Brazil.
Marcos S EndoDepartment of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, State University of Campinas-UNICAMP, Piracicaba, SP, Brazil.
Erica M LopesDepartment of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, State University of Campinas-UNICAMP, Piracicaba, SP, Brazil.
Frederico C MartinhoDivision of Endodontics, Department of Advanced Oral Sciences and Therapeutics, School of Dentistry, University of Maryland, Baltimore, USA.
Brenda P F A GomesDepartment of Restorative Dentistry, Endodontics Division, Piracicaba Dental School, State University of Campinas-UNICAMP, Piracicaba, SP, Brazil.ORCID https://orcid.org/0000-0002-8449-0646

Funding

CAPES 001CNPq 303852/2019-4CNPq 421801/2021-2FAPESP: 2004/11863-0, 2008/56058-9, 2011/50051-5, 2012/23697-4, 2015/19215-2, 2015/23479-5, 2017/16516-7, 2019/14448-0, 2021/14570-0, 2021/13871-6, FAEPEX 2036/17
6 · The paper itself

Abstract

This study aimed to quantify LPS and LTA levels in root canals requiring endodontic retreatment due to secondary or persistent infection and evaluate the relationship between Gram-positive and Gram-negative virulence factors and clinical symptoms and signs. Samples were collected from the root canals of 40 patients who needed endodontic retreatment and had radiographic evidence of apical periodontitis. Lipopolysaccharides (LPS) and lipoteichoic acid (LTA) were quantified using Limulus amebocyte lysate and enzyme-linked immunosorbent assay tests, respectively. LPS and LTA were detected in all samples, with mean values being 5.1 EU/mL(±2.83) and 537.53 pg/mL(±134.14), respectively. Significant correlations were found between levels of LPS and LTA with clinical features. In conclusion, coronal restoration directly influences the load of LPS and LTA in root canals with secondary infection. Furthermore, higher concentrations of endotoxin (LPS) are associated with larger areas of periapical bone resorption, as well as with the presence of clinical signs and symptoms.

Indexed as

Dental Pulp CavityLipopolysaccharidesPeriapical PeriodontitisTeichoic AcidsAdultAgedEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedRoot Canal TherapyLipopolysaccharideslipoteichoic acidTeichoic Acidsendodonticsendotoxinlipoteichoic acid periapical diseaseLPSLTAperiapical diseaseretreatmentvirulence factors

Identifiers

PMID40598979
PMCPMC12351087

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.