Evidence map›Paper›PMID 40598946›Full record

ArticleAnnals of geriatric medicine and research2025

Bidirectional Relationship among Cognitive Function, Muscle Mass, and Grip Strength in Older Adults: the BUSAN Study.

Du-Ri Kim, Jong-Hwan Park, Ting-Fu Lai, Myung-Jun Shin, Tae Sik Goh, Jung Sub Lee, Eunsoo Moon, Yeong-Ae Yang

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In one paragraph

Article in Annals of geriatric medicine and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Du-Ri KimBiomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Jong-Hwan ParkDepartment of Convergence Medicine, Pusan National University School of Medicine, Yangsan, Korea.
Ting-Fu LaiBiomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Myung-Jun ShinBiomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Tae Sik GohBiomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Jung Sub LeeBiomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Eunsoo MoonBiomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Yeong-Ae YangDepartment of Occupational Therapy, College of Biomedical Science and Engineering, Inje University, Gimhae, Korea.

Funding

Busan Metropolitan City
6 · The paper itself

Abstract

backgroundWith the increasing number of older individuals, understanding the interplay among muscle strength, muscle mass, and cognitive functions in aging populations is important. This study aimed to investigate the relationships among muscle mass, muscle strength, and cognitive function among older adults, with a focus on understanding the bidirectional correlations among these factors.

methodsA total of 335 participants aged ≥65 years were analyzed. Comprehensive assessments, including body composition measurements, cognitive function evaluations using the Korean version of Mini-Mental State Examination (K-MMSE), tablet-based cognitive tests, and grip strength measurements were conducted. Statistical analyses included Spearman correlation and binary logistic regression explore the relationships among muscle mass, grip strength, and cognitive function while adjusting for potential confounders.

resultsSignificant correlations were observed among grip strength, lean and skeletal muscle mass index, and cognitive function. Lower grip strength was associated with lower K-MMSE scores, indicating a higher risk of cognitive decline. But lean and skeletal muscle masses index were not associated with cognitive decline. Further analysis revealed a bidirectional relationship, with cognitive decline being associated with reduced grip strength.

conclusionMaintaining muscle strength and mass are important potential strategies to support cognitive health in older individuals. These findings suggest a potential reciprocal relationship where better cognitive function may also contribute to the maintenance or improvement of grip strength. This interconnectedness highlights the importance of considering both physical and cognitive health in aging populations.

Indexed as

AgingCognitionCognitive DysfunctionHand StrengthMuscle, SkeletalMuscle StrengthAgedAged, 80 and overBody CompositionFemaleGeriatric AssessmentHumansMaleMental Status and Dementia TestsRepublic of KoreaAgedCognitionGrip strengthMuscle strengthSarcopenia

Identifiers

PMID40598946
PMCPMC12214992

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.