Cervical vertebrae fusion in elbow knee synostosis (Eks)-mutant mice with fibroblast growth factor 9 N143T mutation.

Georgina Djameh, Masayo Harada, Keiichi Akita

Abstract read

In one paragraph

Article in Congenital anomalies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Cervical vertebrae fusion in elbow knee synostosis (Eks)-mutant mice with fibroblast growth factor 9 N143T mutation.Congenital anomalies
Article

4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Georgina DjamehDepartment of Clinical Anatomy, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8387-5571

Masayo HaradaDepartment of Clinical Anatomy, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0001-8916-5618

Keiichi AkitaDepartment of Clinical Anatomy, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-2927-2937

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proper vertebral column development requires precise segmentation and regulated chondrogenesis during embryogenesis. Mutations affecting fibroblast growth factor 9 (FGF9) signaling disrupt these processes, resulting in abnormal vertebral column development. A missense mutation in FGF9 (p.Asn143Thr) produces elbow knee synostosis (Eks)-mutant mice, which display skeletal fusions, including those in the vertebral column, underscoring the essential role of FGF9 in vertebral segmentation and vertebral joint development. However, the mechanisms regulating joint formation in vertebrae remain elusive. Here, we report that the homozygous Eks mutant mice exhibit neural arch lamina fusion along the rostrocaudal axis at the dorsolateral position in neonates. We investigated the cellular and molecular mechanisms underlying the cervical vertebral fusion in Fgf9

Indexed as

Cervical VertebraeFibroblast Growth Factor 9SynostosisAnimalsChondrocytesChondrogenesisDisease Models, AnimalFemaleGene Expression Regulation, DevelopmentalMiceMutationMutation, MissenseOsteogenesisFgf9 protein, mouseFibroblast Growth Factor 9cartilagecervical vertebraeFGF9fusionmutation

Identifiers

PMID40598912

DOI10.1111/cga.70016

PMCPMC12214759

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.