Evidence map›Paper›PMID 40598790›Full record

ArticleBritish journal of haematology2025

A phase 1, first-in-human, dose-escalation study of JNJ-74856665 (dihydroorotate dehydrogenase inhibitor) alone or in combination in patients with AML or MDS.

Emma Searle, Thomas Cluzeau, Jenny O'Nions, Christian Recher, Emmanuel Gyan, Daniel Morillo, Jordi Esteve, Austin Kulasekararaj, Emmanuel Raffoux, Harriet S Walter and 21 more

Abstract read
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Emma SearleThe Christie NHS Foundation Trust, Manchester, UK.ORCID https://orcid.org/0000-0002-3942-3081
Thomas CluzeauCHU de Nice, Hôpital Archet 1, Nice, France.ORCID https://orcid.org/0000-0002-6745-1127
Jenny O'NionsUniversity College London Hospitals NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-8917-4546
Christian RecherCentre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France.
Emmanuel GyanHématologie et Thérapie Cellulaire, CIC INSERM U1415, Centre Hospitalier Universitaire de Tours, Université de Tours, Tours, France.ORCID https://orcid.org/0000-0002-7651-9189
Daniel MorilloFundación Jiménez Díaz University Hospital, START Madrid-FJD, Madrid, Spain.
Jordi EsteveHospital Clínic de Barcelona, Barcelona, Spain.ORCID https://orcid.org/0000-0002-8056-648X
Austin KulasekararajKing's College Hospital, London, UK.ORCID https://orcid.org/0000-0003-3180-3570
Emmanuel RaffouxHôpital Saint-Louis (AP-HP), Paris, France.
Harriet S WalterUniversity of Leicester, Leicester, UK.
Arnaud PigneuxCentre Hospitalier Universitaire de Bordeaux, Hôpital Haut Lévêque, Bordeaux, France.
David ValcárcelVall d'Hebron, Barcelona, Spain.
Nikki DaskalakisJohnson & Johnson, Spring House, Pennsylvania, USA.
Jacqueline BussolariJohnson & Johnson, Spring House, Pennsylvania, USA.
E Christine PietschJohnson & Johnson, Spring House, Pennsylvania, USA.
Scott KudukJohnson & Johnson, Spring House, Pennsylvania, USA.
Tammy BushJohnson & Johnson, Spring House, Pennsylvania, USA.
Xiaochun ZhangJohnson & Johnson, Spring House, Pennsylvania, USA.
Ulrike PhilipparJohnson & Johnson, Research & Development, Beerse, Belgium.
Adetokunbo OluwasanjoJohnson & Johnson, Spring House, Pennsylvania, USA.
Kathryn BradfordJohnson & Johnson, Spring House, Pennsylvania, USA.
Jonathan MillerJohnson & Johnson, Spring House, Pennsylvania, USA.
Charlotte Van BogaertJohnson & Johnson, Research & Development, Beerse, Belgium.
Martin CurtisJohnson & Johnson, Research Triangle Park, North Carolina, USA.
Shih-Yu ChangJohnson & Johnson, Spring House, Pennsylvania, USA.
Christina GuttkeJohnson & Johnson, Spring House, Pennsylvania, USA.
Stan GajJohnson & Johnson, Research & Development, Beerse, Belgium.
Rachel PearsonJohnson & Johnson, High Wycombe, UK.
Joseph MurphyJohnson & Johnson, High Wycombe, UK.
Wim van DijckJohnson & Johnson, Research & Development, Beerse, Belgium.
Ana Alfonso PiérolaCancer Center Clinica Universidad de Navarra, Pamplona, Spain.

Funding

Johnson and Johnson
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acute myeloid leukaemiadihydroorotate dehydrogenaseJNJ‐74856665myelodysplastic syndromesphase 1

Identifiers

PMID40598790
PMCPMC12379018

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.