Evidence map›Paper›PMID 40598777›Full record

Observational studyArthritis care & research2025

Proportion of Acceptable Symptom State Nearly Tripled With Improvements in Patient-Reported Outcomes for All Symptom State Subgroups: A Registry Study of More Than 15,000 Patients With Osteoarthritis in Digital Education and Exercise Therapy.

Ali Kiadaliri, L Stefan Lohmander, Amanda E Nelson, Leif E Dahlberg

Abstract readObservational Study
In one paragraph

Observational study in Arthritis care & research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ali KiadaliriLund University, Lund, and Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-4254-9099
L Stefan LohmanderLund University, Lund, Sweden.
Amanda E NelsonUniversity of North Carolina, Chapel Hill.ORCID 0000-0002-9344-7877
Leif E DahlbergLund University, Lund, and Arthro Therapeutics, Malmö, Sweden.

Funding

Mentoring in Patient Oriented Research in OsteoarthritisK24AR081368 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Amanda E Nelson · 2022 to 2026
$916k
Greta och Johan Kocks stiftelserNIAMS NIH HHS K24 AR081368NIAMS NIH HHS K24AR081368Stiftelsen för Bistånd åt Rörelsehindrade i Skåne
6 · The paper itself

Abstract

objectiveThis study investigated trajectories of patient acceptable symptom state (PASS) among participants of digital education and exercise therapy for knee and hip osteoarthritis.

methodsA longitudinal observational study among individuals aged at least 40 years who participated in the digital program. Participants completed PASS (yes/no) at enrollment and at least one follow-up during 1 year after enrollment (N = 15,253). Group-based trajectory modeling was used to identify groups with distinct PASS trajectories. We used multinomial logistic regression and linear random intercept models to explore predictors and compare changes in patient-reported outcome measures (PROMs) across trajectory subgroups.

resultsThe proportion of participants reporting acceptable symptom state rose from 17.4% (95% confidence interval [CI] 16.8%-18.1%) at enrollment to 42.4% (95% CI 41.6%-43.1%) and 48.9% (95% CI 47.5%-50.2%) at 3- and 12-month follow-ups, respectively. We identified four PASS trajectories: (1) "persistently not achieving PASS" (PNAP) (45.1%), (2) "early sustained PASS" (ESP) (34.8%), (3) "gradually increasing satisfaction" (GIS) (10.8%), and (4) "early PASS, later unacceptable PASS" (9.3%). Among baseline variables, female sex, older age, nonmetropolitan residence, lower education, knee osteoarthritis, fear of movement, no walking difficulties, no wish for surgery, and better PROMs were generally associated with higher odds of following trajectories other than the PNAP. All trajectories experienced improvements in PROMs, with generally larger improvements in the ESP and GIS groups than the other two groups.

conclusionThe percentage of participants achieving PASS almost tripled at 12 months. Improvements in PROMs across all PASS trajectories highlights the importance of distinction between "feeling better" and "feeling good."

Indexed as

Exercise TherapyOsteoarthritis, HipOsteoarthritis, KneePatient Education as TopicPatient Reported Outcome MeasuresAdultAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedRegistriesTreatment Outcome

Identifiers

PMID40598777
PMCPMC12750131

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.