ArticleJournal of pharmaceutical health care and sciences2025
Incidence of somnolence and dizziness induced by mirogabalin and pregabalin under opioid treatment: a single-center observational study.
Article in Journal of pharmaceutical health care and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Therapeutic potential of combining mirogabalin with antidepressants in relieving hypersensitivity: evidence from a mouse model of neuropathic pain.Pharmacological reports : PR · 2026Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe gabapentinoids pregabalin and mirogabalin are utilized to treat neuropathic pain, especially in patients with cancer receiving opioid analgesics. Pregabalin combined with strong opioids increases somnolence and dizziness, while mirogabalin causes fewer central adverse events. This study aimed to determine whether mirogabalin leads to a lower incidence of somnolence and dizziness than pregabalin in patients with cancer receiving strong opioids.
methodsWe analyzed inpatients with cancer treated with mirogabalin or pregabalin along with strong opioids at Fujita Health University Hospital (April 2019–December 2023) and assessed cumulative incidence rates, hazard ratios (HRs) for somnolence and dizziness occurrence, and changes in morphine milligram equivalents (MMEs).
resultsAmong the 89 patients included in the analysis (mirogabalin: 39, pregabalin: 50), the median time to somnolence and dizziness was significantly shorter in the mirogabalin group than in the pregabalin group (8.0 vs. 17.0 days, p = 0.039). The multivariable Cox proportional regression model showed a higher risk with mirogabalin, although with no significance (HR: 1.74, p = 0.117). MMEs increased in the pregabalin group but not in the mirogabalin group.
conclusionsMirogabalin and pregabalin contribute to somnolence and dizziness in patients receiving strong opioids, necessitating careful monitoring.
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