Evidence map›Paper›PMID 40598644›Full record

ArticleBiology of sex differences2025

Alcohol use during pregnancy: the impact of social determinants of health on alcohol consumption among pregnant women.

MacKenzie R Peltier, Terril L Verplaetse, Vera Bici, Abbie A Mokwuah, C Leonard Jimenez Chavez, Yasmin Zakiniaeiz, Robert Kohler, Vernon Garcia-Rivas, Bubu A Banini, Hang Zhou and 3 more

Abstract read
In one paragraph

Article in Biology of sex differences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Health Promotion and Support Grounded in Interconnected Influences on Alcohol Use in Pregnancy.International journal of environmental research and public health · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

MacKenzie R PeltierYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA. mackenzie.peltier@yale.edu.
Terril L VerplaetseYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA.
Vera BiciYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA.
Abbie A MokwuahYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA.
C Leonard Jimenez ChavezYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA.
Yasmin ZakiniaeizYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA.
Robert KohlerYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA.
Vernon Garcia-RivasYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA.
Bubu A BaniniYale School of Medicine, Section of Digestive Diseases, New Haven, CT, 06519, USA.
Hang ZhouYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA.
Nakul R RavalYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA.
Brian PittmanYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA.
Sherry A McKeeYale School of Medicine, Department of Psychiatry, 40 Temple Street Suite: 5B, New Haven, CT, 06519, USA.

Funding

Yale-SCORE Resource Support CoreU54AA027989 · NIAAA · YALE UNIVERSITY · PI Ralitza Gueorguieva · 2020 to 2026
$13.0M
Phase 2 study examining efficacy and mechanisms of combining varenicline and guanfacine for smoking cessation in women and menR01DA047986 · NIDA · YALE UNIVERSITY · PI MCKEE, SHERRY ANN · 2020 to 2022
$2.3M
Characterizing brain-periphery cortisol dysregulation in AUDR01AA030971 · NIAAA · YALE UNIVERSITY · PI Terril L Verplaetse · 2024 to 2026
$2.1M
Behavioral and Neurochemical Mechanisms Underlying Stress-Precipitated DrinkingK01AA025670 · NIAAA · YALE UNIVERSITY · PI VERPLAETSE, TERRIL L · 2018 to 2023
$882k
Sex Differences in Alcohol Use Disorder Neurodegeneration using Multimodal PET and DTI NeuroimagingK01AA029706 · NIAAA · YALE UNIVERSITY · PI Yasmin Zakiniaeiz · 2022 to 2026
$881k
Adolescent Binge Ethanol Dysregulation of H3K36me3 Leads to Cryptic Transcription and Lasting Memory DeficitsF31AA029259 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI BROCATO, EMILY ROSE · 2021 to 2022
$74k
National Institute of Alcohol Abuse and Alcoholism K01AA025670-04National Institute of Alcohol Abuse and Alcoholism K01AA029706National Institute of Alcohol Abuse and Alcoholism T32AA029259National Institute of Alcohol Abuse and Alcoholism U54AA027989National Institute of Drug Abuse R01DA047986NIAAA NIH HHS F31 AA029259NIAAA NIH HHS K01 AA025670NIAAA NIH HHS K01 AA029706NIAAA NIH HHS R01 AA030971NIAAA NIH HHS R01AA030971NIAAA NIH HHS U54 AA027989NIDA NIH HHS R01 DA047986Office of the Assistant Secretary of Defense for Health Affairs through the Alcohol and Substance Use Research Program W81XWH-22-2-0081, PASA3Veteran's Affairs VISN1 CDA
6 · The paper itself

Abstract

backgroundThere is no safe amount or time of alcohol consumption during pregnancy; however, many women drink while pregnant placing themselves and their fetuses at risk for alcohol-related health complications. Social Determinants of Health (SDoH) impact alcohol use during pregnancy. Understanding the impact of SDoH across pregnancy will elucidate important information to reduce rates of prenatal alcohol exposure.

methodsCross-sectional data from the National Survey of Drug Use and Health from 2009 to 2019 was used to explore the impact of SDoH on alcohol use across pregnancy. The study assesses past month alcohol use and past month binge drinking, as well as various SDoH. The sample included 8,638 pregnant women.

resultsOver 9% of pregnant women reported alcohol use within the past 30 days and 5.25% reported drinking on three or more days within the past month. 3.65% reported past month binge drinking. Past month alcohol use and past month binge drinking decreased in the second and third trimesters; however, a subset of women continued alcohol use, including binge drinking. Specific SDoH emerged as increasing the likelihood of alcohol use within the past month, including not being married (ORs = 1.54 to 1.94), criminal justice involvement (arrested and booked; OR = 1.88), and past year psychiatric distress (OR = 1.86). Conversely, other determinants were associated with a lower likelihood of alcohol use, including identifying as Asian or Hispanic (ORs = 0.41 and 0.64) and unemployment (OR = 0.52) and other employment (OR = 0.66). Older age was associated with a lower likelihood of binge drinking within the past month (ORs = 0.32). Unique SDoH emerged when examining alcohol use by trimester.

conclusionSpecific SDoH (i.e., not married, criminal justice involvement, past year psychiatric distress) are related to increased alcohol use during pregnancy, while other determinants (i.e., identifying as Asian or Hispanic, not requiring full time/part-time employment) are associated with a decreased risk for past month alcohol use. Older individuals (35-49 years old) and those with a high school education had a decreased likelihood of binge drinking. Accordingly, healthcare providers should screen all pregnant women for alcohol use throughout pregnancy, especially among populations or groups identified as being vulnerable to continue alcohol use during pregnancy.

Indexed as

Alcohol DrinkingEthanolSocial Determinants of HealthSociodemographic FactorsAdolescentAdultChildFemaleHumansLikelihood FunctionsMiddle AgedPregnancyPregnancy ComplicationsSurveys and QuestionnairesYoung AdultEthanolAlcohol usePregnancyProblematic drinkingSDoHTrimester

Identifiers

PMID40598644
PMCPMC12219128

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.