Evidence map›Paper›PMID 40598589›Full record

ArticleNutrition journal2025

The interplay of genetics and fatty acid metabolism: exploring their impact on metabolic syndrome in Swedish men.

Harpa Oskarsdottir, Arnar Palsson, Erla B Olafsdottir, Vilmantas Giedraitis, Salahuddin Mohammad, Ulf Risérus, Helgi B Schiöth, Gudrun V Skuladottir, Jessica Mwinyi

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In one paragraph

Article in Nutrition journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Harpa OskarsdottirDepartment of Physiology, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Arnar PalssonInstitute of Life and Environmental Sciences, University of Iceland, Reykjavík, Iceland.
Erla B OlafsdottirInstitute of Life and Environmental Sciences, University of Iceland, Reykjavík, Iceland.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
Salahuddin MohammadDepartment of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, Uppsala, Sweden.
Ulf RisérusDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
Helgi B SchiöthDepartment of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, Uppsala, Sweden. helgi.schioth@uu.se.
Gudrun V Skuladottir *Department of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, Uppsala, Sweden.
Jessica Mwinyi *Department of Surgical Sciences, Functional Pharmacology and Neuroscience, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic risk variants for obesity and metabolic syndrome (MetS) have been identified, but their link to relevant metabolic health parameters warrants further attention. This study aimed to investigate the extent to which single-nucleotide polymorphisms (SNPs) associated with obesity are linked to changes in fatty acid (FA) profiles in serum cholesteryl esters, lipid metabolism, and MetS risk.

methodData from the Uppsala Longitudinal Study of Adult Men (ULSAM), conducted in men at age 50 (N = 1973) and age 70 (N = 982), were used to investigate SNPs associated with body mass index (BMI) in genome-wide association studies with metabolic parameters at age 50. The significant SNPs and associated lipid parameters were then used as predictors of MetS over a 20-year follow-up period, at age 70 in binary regression models.

resultsThe two genes, the brain-derived neurotrophic factor gene (BDNF) (rs7103411) and the fat mass and obesity-associated gene (FTO) (rs1558902), together with delta-5-desaturase (D5D) activity, 20:5n-3 in serum cholesteryl esters (CE), fasting blood glucose, abdominal skinfold thickness, apolipoprotein-B, and high-density lipoprotein cholesterol (HDL-C) at age 50, significantly predicted the risk of MetS at age 70.

conclusionThe findings suggest a considerable contribution of the SNPs BDNF rs7103411, FTO rs1558902, and ETV5 rs9816226, along with low D5D activities and serum levels of HDL-C in men at age 50, to the risk for MetS 20 years later.

Indexed as

Fatty AcidsMetabolic SyndromePolymorphism, Single NucleotideAgedAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody Mass IndexCholesterol EstersDelta-5 Fatty Acid DesaturaseGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLipid MetabolismLongitudinal StudiesMaleMiddle AgedObesityAlpha-Ketoglutarate-Dependent Dioxygenase FTOCholesterol EstersDelta-5 Fatty Acid DesaturaseFatty AcidsFTO protein, humanApolipoprotein BDelta-5-desaturaseFatty acidsHigh-density lipoprotein cholesterolMetabolic syndromeSerum cholesteryl esterSingle-nucleotide polymorphisms

Identifiers

PMID40598589
PMCPMC12210471

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.