Evidence map›Paper›PMID 40598567›Full record

ArticleGenome medicine2025

High genetic relatedness between multidrug resistant bacteria before and after the 2022 invasion of Ukraine.

Francois Lebreton, Viacheslav Kondratiuk, Valentyn Kovalchuk, Niels Pfennigwerth, Ting L Luo, Brendan T Jones, Nadiia Fomina, Frieder Fuchs, Jörg B Hans, Jessica Eisfeld and 4 more

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In one paragraph

Article in Genome medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Francois Lebreton *Multidrug-Resistant Organism Repository and Surveillance Network (MRSN), Diagnostics and Countermeasures Branch, CIDR, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Room 2A36, Silver Spring, MD, 20910, USA.
Viacheslav Kondratiuk *Department of Emergency and Military Medicine, National Pirogov Memorial Medical University, Vinnytsia, Ukraine.
Valentyn KovalchukDepartment of Microbiology, National Pirogov Memorial Medical University, Vinnytsia, Ukraine.
Niels PfennigwerthNational Reference Centre for Multidrug-Resistant Gram-Negative Bacteria, Department of Medical Microbiology, Ruhr-University Bochum, Bochum, 44801, Germany.
Ting L LuoMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Diagnostics and Countermeasures Branch, CIDR, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Room 2A36, Silver Spring, MD, 20910, USA.
Brendan T JonesMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Diagnostics and Countermeasures Branch, CIDR, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Room 2A36, Silver Spring, MD, 20910, USA.
Nadiia FominaDepartment of Microbiology, National Pirogov Memorial Medical University, Vinnytsia, Ukraine.
Frieder FuchsDepartment of Microbiology and Hospital Hygiene, Bundeswehr Central Hospital Koblenz, Koblenz, 56072, Germany.
Jörg B HansNational Reference Centre for Multidrug-Resistant Gram-Negative Bacteria, Department of Medical Microbiology, Ruhr-University Bochum, Bochum, 44801, Germany.
Jessica EisfeldNational Reference Centre for Multidrug-Resistant Gram-Negative Bacteria, Department of Medical Microbiology, Ruhr-University Bochum, Bochum, 44801, Germany.
Ana OngMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Diagnostics and Countermeasures Branch, CIDR, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Room 2A36, Silver Spring, MD, 20910, USA.
Sören GatermannNational Reference Centre for Multidrug-Resistant Gram-Negative Bacteria, Department of Medical Microbiology, Ruhr-University Bochum, Bochum, 44801, Germany.
Jason W BennettMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Diagnostics and Countermeasures Branch, CIDR, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Room 2A36, Silver Spring, MD, 20910, USA.
Patrick Mc GannMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Diagnostics and Countermeasures Branch, CIDR, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Room 2A36, Silver Spring, MD, 20910, USA. patrick.t.mcgann4.civ@health.mil.

Funding

German Ministry of Health 1369-402Ukrainian Ministry of Health 0117U00690
6 · The paper itself

Abstract

backgroundThe Russian invasion of Ukraine in 2022 has placed extraordinary pressure on hospitals there. One consequence of this has been the alarming increase in infections caused by multi-drug resistant organisms (MDROs), both within Ukraine and among the Ukrainian diaspora. The original source of these MDROs remains obscure although nosocomial origin is suspected. Here, we analyzed a collection of Acinetobacter baumannii and Pseudomonas aeruginosa collected from Ukraine before and after the invasion to glean a greater understanding of their relationship and origins.

methodsGenomic analysis was conducted on 167 A. baumannii and 93 P. aeruginosa cultured from 223 Ukrainian patients hospitalized in Ukraine or other European countries. Fifty-three isolates were cultured between 2014 and 2021, prior to the invasion, and the remaining 207 after.

resultsHighly genetically related extensively-drug resistant (XDR) clones were identified that spanned the pre- and post-invasion periods. For A. baumannii, isolates encompassed three sequence types (STs), including carbapenemase-producing strains from ST-2 (bla

conclusionsXDR epidemic clones circulating in Ukraine and across Europe since 2022 share a close genetic relationship to historical strains from Ukraine. In some cases, direct links to medical facilities within Ukraine can be inferred. These data suggest that surveillance efforts should focus on tracking nosocomial transmission within Ukrainian hospitals while infection control efforts are being disrupted by the ongoing Russian invasion.

Indexed as

Acinetobacter baumanniiDrug Resistance, Multiple, BacterialPseudomonas aeruginosaCross InfectionHumansUkraineA. baumanniiAntimicrobial resistanceCarbapenem resistanceMicrobial genomicsMolecular epidemiologyNosocomial outbreakP. aeruginosaSurveillance

Identifiers

PMID40598567
PMCPMC12220160

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.