Evidence map›Paper›PMID 40598551›Full record

ArticleJournal of nanobiotechnology2025

A Self-Generated Electricity-Driven Sclera reinforcement bionic piezoelectric patch for Management of High Myopia.

Lingxi Jiang, Bo Zhao, Qi Li, Chunbao Xie, Jiale Hong, Yiwei Wan, Yukai Gong, Zhengzheng Wu, Liang Zou, Yang-Bao Miao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. [Research progress and applications of biologically derived materials in scleral reconstruction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lingxi Jiang *Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Bo Zhao *Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Qi Li *Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Chunbao Xie *Sichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Jiale HongDepartment of Hematology, Sichuan Provincial People's Hospital, School of Medicine, Sichuan Academy of Medical Sciences, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Yiwei WanSichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Yukai GongSchool of Food and Biological Engineering, Chengdu University, Chengdu, Sichuan, 610106, China.
Zhengzheng WuSichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Liang ZouSchool of Food and Biological Engineering, Chengdu University, Chengdu, Sichuan, 610106, China.
Yang-Bao MiaoDepartment of Hematology, Sichuan Provincial People's Hospital, School of Medicine, Sichuan Academy of Medical Sciences, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China. miaoyangbao@uestc.edu.cn.
Yi ShiSichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China. shiyi1614@126.com.

Funding

National Natural Science Foundation of China 32401173National Natural Science Foundation of China 82201234National Natural Science Foundation of China 82271120Sichuan Science and Technology Program 2024ZHYS0018TOP Young Talents Program of Sichuan DQ202407
6 · The paper itself

Abstract

backgroundHigh myopia (HM) is a progressive ocular condition characterized by excessive axial elongation and severe refractive errors, often leading to sight-threatening complications. The underlying pathological driver of HM is the weakening of scleral biomechanics, making the sclera a key therapeutic target. While posterior scleral reinforcement (PSR) has been established as an effective intervention to strengthen the sclera, currently available PSR materials often fail to fully meet clinical demands.

resultsInspired by the electric eel, which generates surface electrolytes to facilitate electric discharge and influence interactions with its surroundings, we developed a biomimetic piezoelectric patch (BPP@PVDF) for HM treatment. This patch integrates a bovine pericardium (BPP) scaffold with a piezoelectric polyvinylidene fluoride (PVDF) film, endowing the BPP with electrical properties and improved cell adhesion. Through electrical activation, the BPP enhances scleral mechanical strength and promotes collagen synthesis, effectively mitigating axial elongation in myopia.

conclusionsBoth in vitro and in vivo experiments demonstrate that our precisely designed patch provided a stable and effective solution for reducing progressive axial elongation in HM. By leveraging nanotechnology, electrical stimulation, and scleral reinforcement surgery, this study offers a groundbreaking approach with significant implications for both scientific research and clinical practice. Our strategy paves the way for enhanced surgical outcomes in HM treatment, offering a promising avenue for future therapeutic advancements.

Indexed as

BionicsMyopiaScleraAnimalsCattleElectricityFluorocarbon PolymersHumansPericardiumPolyvinylsFluorocarbon Polymerspolyvinylidene fluoridePolyvinylsHigh myopiaPolyvinylidene fluoridePosterior scleral reinforcement

Identifiers

PMID40598551
PMCPMC12211304

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.