ReviewStem cell research & therapy2025
Engineering strategies to enhance the research progress of mesenchymal stem cells in wound healing.
Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Smart integrated biomaterial systems for precision and optimized delivery of MSCs and their exosomes: Transforming wound healing and organ regeneration.Regenerative therapy · 2026Review
- Article
- GPCRs as key regulators in wound healing.Frontiers in cell and developmental biology · 2026Review
- Advances in enhanced mesenchymal stem cell technologies: innovations and therapeutic applications.Frontiers in cell and developmental biology · 2026Review
- Valproic acid boosts hair follicle stem cell resilience to oxygen-glucose deprivation through autophagy induction and AKT/mTOR suppression.Scientific reports · 2025Article
- Stem Cell and Exosome Therapy in Wound Healing: Traps, Paradoxes, and Tricks Transforming Paradigms.Biomedicines · 2025Article
- Current status and new horizons in stem cell therapy in cardiovascular regenerative medicine (CaVaReM): an update.European journal of medical research · 2025Review
- Advancements in mesenchymal stem cell therapy for chronic wounds: challenges, innovations, and future directions.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Wound healing is a multifaceted biological process involving critical phases such as inflammation modulation, tissue regeneration, and angiogenesis. Traditional therapies often yield inconsistent results. Mesenchymal stem cells (MSCs)—with their abilities for self-renewal, tissue repair, angiogenesis, and immunomodulation—represent a promising avenue in regenerative medicine and wound healing. However, the efficacy of MSCs is frequently compromised by the hostile post-transplantation microenvironment. Recent advances in engineering strategies—including gene modification, preconditioning, biomaterial scaffolds, and hydrogels—have significantly enhanced the therapeutic potential of MSCs by improving their survival, proliferation, and migration. Moreover, the combined application of multiple engineering approaches further optimizes wound healing outcomes by accelerating tissue repair and reducing scar formation. In this review, we systematically summarize the mechanisms underlying MSC-mediated wound healing, their clinical applications, and the impact of various engineering strategies, with the aim of facilitating the clinical translation of engineered MSCs and providing more effective therapeutic solutions.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.