Evidence map›Paper›PMID 40598488›Full record

ArticleJournal of nanobiotechnology2025

Alternating magnetic field-responsive engineered probiotics for anxiety therapy via gut-brain axis modulation.

Xuejun Wang, Yuhan Zhang, Yuling Chang, Yuhao Zhu, Guo Xiang, Kehua Chen, Chuanxing Feng, Zhaofang Hang, Xingang Li, Di Zhang

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Targeting the intestinal TLR4-GABAJournal of neuroinflammation · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuejun WangJinan Microecological Biomedicine Shandong Laboratory, Jinan, 250017, PR China.
Yuhan ZhangJinan Microecological Biomedicine Shandong Laboratory, Jinan, 250017, PR China.
Yuling ChangJinan Microecological Biomedicine Shandong Laboratory, Jinan, 250017, PR China.
Yuhao ZhuJinan Microecological Biomedicine Shandong Laboratory, Jinan, 250017, PR China.
Guo XiangDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Institute of Brain and Brain-Inspired Science, Shandong University, 107 Wenhuaxi Rd, Jinan, 250012, PR China.
Kehua ChenDepartment of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Institute of Brain and Brain-Inspired Science, Shandong University, 107 Wenhuaxi Rd, Jinan, 250012, PR China.
Chuanxing FengJinan Microecological Biomedicine Shandong Laboratory, Jinan, 250017, PR China.
Zhaofang HangJinan Microecological Biomedicine Shandong Laboratory, Jinan, 250017, PR China.
Xingang LiJinan Microecological Biomedicine Shandong Laboratory, Jinan, 250017, PR China. lixg@sdu.edu.cn.
Di ZhangJinan Microecological Biomedicine Shandong Laboratory, Jinan, 250017, PR China. dizhang@sdu.edu.cn.

Funding

Natural Science Foundation of Shandong Province ZR2023QH322Research Project of Jinan Microecological Biomedicine Shandong Laboratory JNL-202203QShandong Provincial Laboratory Project SYS202202Special Foundation for Taishan Scholars tsqn202211283the National Natural Science Foundation of China 82071512the Natural Science Foundation of Shandong Province ZR2019ZD33
6 · The paper itself

Abstract

The discovery of the gut-brain axis demonstrated bidirectional regulation between the gut and the brain. The gastrointestinal branches of the vagal nerve have been proven to directly modulate multiple functions of the central nervous system (CNS), providing great opportunities to develop novel tools to remotely regulate CNS function from the gut. Engineered bacteria, acting as oral live biotherapeutics, offer a durable and controllable way of modulating neuronal function non-invasively and with low side effects. Here, we constructed an engineered bacterium by genetically modifying Escherichia coli Nissle 1917 (EcN) with Fe

Indexed as

AnxietyBrainBrain-Gut AxisProbioticsAnimalsAnti-Anxiety AgentsEscherichia coligamma-Aminobutyric AcidGastrointestinal MicrobiomeGastrointestinal TractMagnetic FieldsMagnetite NanoparticlesMaleMiceMice, Inbred C57BLAnti-Anxiety Agentsgamma-Aminobutyric AcidMagnetite NanoparticlesAnxiety therapyEngineered bacteriaGastrointestinal vagal afferentsGut-brain axisNanomaterials

Identifiers

PMID40598488
PMCPMC12211363

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.