ArticleBMC medicine2025
Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dynamic frontoparietal flexibility and cognitive dysfunction in schizophrenia: disentangling the roles of symptom burden and childhood trauma.Psychological medicine · 2026Article
- Correction: Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings.BMC medicine · 2026Article
- Learning evoked centrality dynamics in the schizophrenia brain: entropy, heterogeneity, and inflexibility of brain networks.Journal of psychiatry & neuroscience : JPN · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
backgroundWorking memory (WM) deficits are a key feature of schizophrenia and are also seen in unaffected siblings. These deficits might arise from disrupted transitions from one brain state to another. Using a robust algorithm called the Bayesian Switching Dynamical System (BSDS), we studied hidden brain states and their transitions during a WM task in people with schizophrenia.
methodsWe used BSDS to identify brain states based on regions of interest (ROIs) within the default mode network and the frontoparietal network in 161 patients with schizophrenia, 37 unaffected siblings, and 96 healthy controls during N-back (0, 2, and resting fixation) tasks. We estimated group differences in the properties of brain states and studied the influence of WM performance and clinical characteristics on them using General Linear Models.
resultsWe identified 4 brain states underlying the WM task: high-demand, low-demand, fixation, and non-dominant states. Compared with controls and siblings, patients showed reduced occupancy and lifetime of high-demand state during the "2-back," reduced lifetime of low-demand state during the "0-back," but increased occupancy and lifetime of fixation state during both task periods. Aberrant high-demand state mediated the association between WM performance and negative symptoms. Compared with controls and patients, siblings showed increased occupancy of high-demand and reduced fixation state during the resting fixation condition; this putative compensatory process correlated with better WM performance.
conclusionsLatent brain states of intrinsic connectivity that represent internal mental processes affect WM performance, influencing the expression of negative symptoms in schizophrenia and cognitive resilience in unaffected siblings.
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