Evidence map›Paper›PMID 40598399›Full record

ArticleBMC biology2025

Refining the genetic structure and admixture history of Hmong-Mien populations.

Meiqing Yang, Huangzhen Huang, Han Zhang, Wen Wan, Kongyang Zhu, Rui Wang, Jinxi Li, Lu Chen, Jiang Huang, Chuan-Chao Wang

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Article in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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10 authors.

Meiqing Yang *Department of Forensic Medicine, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical University, Guiyang, 561113, China.
Huangzhen Huang *Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Han ZhangDepartment of Forensic Medicine, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical University, Guiyang, 561113, China.
Wen WanDepartment of Forensic Medicine, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical University, Guiyang, 561113, China.
Kongyang ZhuState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Rui WangMinistry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Jinxi LiZhangjiang Fudan International Innovation Center, Human Phenome Institute, Fudan University, Shanghai, China.
Lu ChenMinistry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Jiang HuangDepartment of Forensic Medicine, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Guizhou Medical University, Guiyang, 561113, China. mmm_hj@126.com.
Chuan-Chao WangMinistry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China. chuanchaowang@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent studies have shed light on the unique linguistic and genetic characteristics of Hmong-Mien speakers. However, the underlying genetic structure and admixture events that shape their genetic diversity remain inadequately elucidated.

resultsHere, we co-analyzed newly generated genome-wide data from 164 individuals in Guizhou Province with published data from geographically proximate HM speakers using both allele frequency-based and haplotype-based methods. We unveiled fine-scale genetic substructure within HM speakers in southwest China, emphasizing distinct genetic differentiation between the Miao and Yao branches. Notably, Guangxi GaoHuaHua individuals showed close affiliation with the Yao branch, indicating a divergence time predating approximately 500 years ago. Besides, southwestern HM speakers exhibited an admixture pattern of indigenous Hmong and BaikuYao-like ancestry with minor contributions from neighboring populations like Tai-Kadai and Sino-Tibetan speakers in recent history. We finally identified the dominant paternal and diverse maternal lineages of HM speakers, implying a rich genetic tapestry and intricate historical migrations.

conclusionsOur study provided new insights into the genetic formation and admixture events that significantly shaped the genomic diversity of present-day HM speakers in southwest China.

Indexed as

Asian PeopleEthnicityGenetics, PopulationGenetic VariationChinaGene FrequencyHaplotypesHumansAdmixtureFine-scaleGenetic structureGenomic diversityHmong-MienRecent ancestrySouthwest China

Identifiers

PMID40598399
PMCPMC12217280

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