ArticleStem cell research & therapy2025
Tensile stress promotes the chondrogenic ability of condylar cartilage stem/progenitor cells in the temporomandibular joint via the Piezo1-Ca
Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Article
- Article
- Integrative multi-omics analysis prioritizes compartment-specific candidate targets of gut microbiota metabolites in diabetic kidney disease.Frontiers in immunology · 2026Article
- MicroRNA-mediated mechanotransduction and chondrocyte differentiation in mesenchymal stem cells.Animal cells and systems · 2026Review
- Piezo1-Fstl1 Axis in Fracture Healing: Modulation of the Chondrocyte Inflammation-ROS-Mitochondrial Damage Cascade and Application of Smart Delivery System.International journal of biological sciences · 2026Article
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Abstract
backgroundTensile force is a key regulator for condylar cartilage remodeling in the temporomandibular joint (TMJ), and this biomechanical characteristic underlies the mechanisms of mandibular growth modification in orthodontic practice. Cartilage stem/progenitor cells (CSPCs) in the superficial layer of condylar cartilage play an essential part in the development and remodeling of condylar cartilage. However, the regulatory role of tensile force on condylar CSPCs remains unclear. This study aimed to investigate the impact of tensile loading on condylar CSPCs and explore the molecular mechanisms within.
methodsThe mandibular advancement (MA) model was constructed to apply tensile force on the condylar cartilage in vivo. Flow cytometry and transcriptome sequencing were utilized to assess the percentage of CSPCs and gene expression in the superficial layer of rat condylar cartilage. Lineage tracing with cathepsin K (Ctsk) in mice was employed to trace the differentiation of CSPCs. 10% equibiaxial dynamic strain was loaded on rat CSPCs for cell stretching in vitro. GsMTx4 was used to inhibit the Piezo1 channel, and the calcium chelating agent BAPTA was used to block the Ca
resultsCartilage thickening and a transient reduction of the CSPCs proportion in the superficial layer of the condylar cartilage were observed after 1 week of MA. The ratio of Ctsk and type II collagen double-positive cells climbed in the first week after MA, and 2 weeks later, the ratio of Ctsk and EdU double-positive cells rose. The expression level of chondrogenic-related genes, Piezo1, and Prkca was elevated in CSPCs after tensile loading. GsMTx4 and BAPTA could block the Ca
conclusionsWe uncovered that tensile stress could cause a transient shrinkage of the CSPCs pool in condylar cartilage, resulting from the accelerated chondrogenesis of CSPCs. Tensile force could promote the chondrogenic ability of CSPCs via the Piezo1-Ca
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