ArticleBMC veterinary research2025
Faecal microbiota and serum metabolome association with equine metabolic syndrome in connemara ponies.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- From Diet to Disease: The Role of the Gut Microbiome and Microbial Metabolites in Horses.Veterinary sciences · 2026Review
- Using Gut Microbiota and Gut Metabolites as Biomarkers for Diseases in Monogastric Farm Animals.Animals : an open access journal from MDPI · 2026Review
- A Comprehensive Review of the Equine Gut Microbiome in Health and Disease.Veterinary sciences · 2026Review
- Long-Read Sequencing for Species-Level Resolution of the Equine Gut Microbiota Reveals the Need for Improved Databases.Animals : an open access journal from MDPI · 2026Article
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Authors and funding
10 authors.
Funding
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Abstract
backgroundFaecal microbiome and serum metabolome have been studied in human medicine to provide a better understanding of metabolic derangements including diabetes; however, equivalent studies in equine medicine are limited. This was a case-control study conducted to identify differences in faecal microbiota composition and concurrent serum metabolite patterns between metabolically normal Connemara ponies and those with Equine Metabolic Syndrome (EMS). Thirty privately owned Connemara ponies (15 EMS and 15 controls) were included in the study. EMS was diagnosed by oral sugar test (OST). Blood samples were collected before and after an oral sugar challenge. One concurrent faecal sample was collected from each pony. Sequencing of the V3-V4 region of 16S rRNA gene was used to identify the microbial communities in faecal samples and assess the differences in microbial profiles between groups. Serum metabolites were analyzed using liquid chromatography-high-resolution mass spectrometry (LC-MS). Finally, multi-omics analysis was conducted by integration of microbiota-metabolome datasets to determine potential associations between metabolites and microbiota in EMS.
resultsThe faecal microbiota community composition was significantly different between EMS and control groups (p = 0.04 and r
conclusionsThis study suggests that concurrent faecal microbiota and serum metabolome features significantly differ between Connemara ponies with and without EMS. These results provide insights that may assist in the search for diagnostic markers associated with microbiota changes and novel preventative management methods to manipulate microbiota in horses with EMS.
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