ReviewJournal of translational medicine2025
CyTOF as a suitable tool for stratification and monitoring of cancer patients.
Review in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Quantitative Single-Cell Multielemental Analysis Using Metal-Loaded Microparticles: toward a Universal Quantification Workflow in Mass Cytometry.Analytical chemistry · 2026Article
- Cyclic immunofluorescence platform using photocleavable linkers for direct antibody labeling enables cancer phenotyping.bioRxiv : the preprint server for biology · 2026Article
- Single-cell CyTOF profiling reveals alterations in B, T and macrophage subsets during murine hepatic aging.Frontiers in immunology · 2026Article
- Review
- Pan-cancer convergence of tumour-immune microenvironment motifs revealed by CyTOF and imaging mass cytometry.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Despite the recent implementation of immunotherapies into clinical practice of various tumor types, the immunobiology of tumors and in particular the role and clinical relevance of the different immune cell populations and their function still remained unclear. Therefore, an in depth analysis of the complex landscape of immune cell populations and their soluble mediators in the peripheral blood and tumor microenvironment of cancer patients is urgently needed. Mass cytometry has revolutionized the immune phenotyping in particular in settings where simultaneous breadth and detailed characterization of the phenotype and function of immune cell (sub)populations with limited sample size is required, such as monitoring of patients' response to immunotherapies. Since mass cytometry is a powerful multiplex approach to decipher tumor intrinsic and tumor extrinsic effects of tumor immunotherapies, this review summarizes the use of this technology for determination of the frequency and functional status of immune cell populations within the tumor and in the blood leading to the identification of intratumoral/peripheral immune signatures that might serve as biomarkers (i) for treatment response and/or failure, (ii) for the stratification of tumor patients or (iii) for the identification of novel therapeutic targets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.