ArticleBMC nursing2025
Impact of nurse-led interventions with prescriptive authority on blood pressure control in hypertension management: a systematic review and meta-analysis.
Article in BMC nursing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Collaborative Primary-Care Workforce Models: An Integrative Review of Evidence Informing RN Prescriber Integration with Family Physicians and Nurse Practitioners.Healthcare (Basel, Switzerland) · 2026Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince the 1960s, advanced practice nurses have gradually emerged worldwide. They are playing an increasingly role in hypertension management, due to their field of expertise at the interface of nursing and medicine. However, there seems to be little evidence to date of their impact on blood pressure control in hypertension management, even though this is a major chronic pathology, with significant cardiovascular morbidity and mortality. Given the lack of trials assessing advanced practice nurse-led interventions in hypertension management, this systematic review and meta-analysis aimed to evaluate the effectiveness of nurse-led interventions with prescriptive authority in improving BP control compared to usual physician-led care.
methodA systematic review and meta-analysis of randomized controlled trials (RCTs) focused on our topic were conducted. A random-effects model was used to estimate pooled mean differences for BP reduction and odds ratios (OR) for BP control. Sensitivity analyses and publication bias assessments were performed.
resultsA meta-analysis of five RCTs showed a significant reduction in systolic BP (-17.73 mmHg, 95% CI: -29.19 to -6.27, p = 0.0024, I² = 99.1%). After excluding two highly influential studies, the effect remained significant (-16.54 mmHg, 95% CI: -23.26 to -9.83, p < 0.001) with reduced heterogeneity (I² = 78.4%). For diastolic BP, a meta-analysis of four RCTs reported a reduction of -9.96 mmHg (95% CI: -18.56 to -1.36, p = 0.0232, I² = 95.6%), which remained significant after sensitivity analysis (-13.25 mmHg, 95% CI: -21.63 to -4.87, p = 0.0019, I² = 89.4%). No robust conclusion could be drawn for BP control (OR) due to the limited number of studies.
conclusionNurse-led interventions with prescriptive authority significantly reduced blood pressure levels versus usual physician-led care. These findings support the implementation of advanced practice nurses (or similar) in hypertension management, but more research is needed to improve the evidence given the significant lack of data in the literature. CLINICAL TRIAL NUMBER: Not applicable.
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