ArticleBMC ophthalmology2025
Correlating retinal and choroidal vascular parameters with volumetric MRI in Alzheimer's disease and amnestic mild cognitive impairment.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03233646 (Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnosing neurodegenerative disorders using retina as an external window: A systematic review of OCT-MRI correlations.Journal of Alzheimer's disease : JAD · 2025Pooled it
- Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Chain Concentrations Are Inversely Associated with Retinal Microvascular Perfusion and Vessel Density in Cognitively Normal Individuals with Familial or Genetic Risk Factors for Alzheimer's Disease.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundWe assess the relationships between retinal and choroidal structural and microvascular parameters and brain volumetric magnetic resonance imaging (MRI) parameters in individuals with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD).
methodsParticipants underwent optical coherence tomography (OCT) and OCT angiography (OCTA) imaging using the Zeiss Cirrus HD-5000 AngioPlex (Carl Zeiss Meditec, Dublin, CA) and volumetric brain MRI imaging with NeuroQuant (CorTechs Labs, San Diego, CA) analysis. Retinal and choroidal structural and microvascular parameters were extracted from OCT and OCTA scans. Superficial capillary plexus perfusion density and vessel density in the 3 × 3 mm and 6 × 6 mm circles and rings centered on the fovea were determined. Hippocampal, superior lateral ventricle (SLV), and inferior lateral ventricle (ILV) volumes were determined. Correlations between OCT, OCTA, and volumetric MRI parameters in patients with aMCI and AD were explored using Spearman partial correlation analysis.
results68 eyes of 37 aMCI participants and 64 eyes of 33 AD participants were analyzed. In the eyes with aMCI, hippocampal volume negatively correlated with FAZ area and positively correlated with perfusion density and vessel density in the 3 mm OCTA scan. In the aMCI cohort, SLV and ILV volume inversely correlated with perfusion density in the 3 mm and 6 mm OCTA scans, respectively. In the eyes with AD, SLV and ILV volume inversely correlated with perfusion density and vessel density in the 3 mm and 6 mm OCTA scans. Central subfield thickness, ganglion cell-inner plexiform layer thickness, RNFL thickness, and choroidal vascularity index did not significantly correlate with SLV, ILV, or hippocampal volume in any cohorts (p > 0.05).
conclusionsDecline in retinal microvascular parameters significantly correlated with hippocampal volume loss and ventricular expansion, suggesting that these parameters may mirror cerebral neurodegeneration in individuals with aMCI and AD.
trial registrationClinical trial identifier: NCT03233646, registration date: July 20, 2017.
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