ArticleBMC cancer2025
Sleep disturbance, cancer-related fatigue, and depression as determinants of quality of life among breast cancer patients undergoing chemotherapy: a cross-sectional study.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Digital Health Interventions and Psychosocial Outcomes in Women With Breast Cancer: Systematic Review.JMIR cancer · 2026Pooled it
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- Stress Response During a Three-Month Follow-Up of a Historical Cohort of People with Cancer: Subjective Hyper-Energy and the DYMERS Framework for a Future Preventive Approach.Journal of clinical medicine · 2026Article
- Beyond surgical risk: Multidimensional predictors of postoperative arm morbidity after breast cancer treatment.Breast (Edinburgh, Scotland) · 2026Article
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- Supportive care needs and quality of life in caregivers of cancer patients receiving home-based palliative care: a serial mediation model.BMC palliative care · 2026Article
- Quality of Life in Slovak Breast Cancer Survivors: A Cross-Sectional Study Using EORTC QLQ-C30 and BR23.Nursing reports (Pavia, Italy) · 2026Article
- Joint nausea and fatigue profiles during chemotherapy identify patients with a higher symptom burden.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Article
- Systems approach to integrative oncology in breast cancer care: service design, delivery and patient experiences from a UK center.Frontiers in oncology · 2026Article
- A latent profile analysis of cancer-related fatigue in patients with breast cancer undergoing chemotherapy and its relationship with quality of life: a cross-sectional study.Frontiers in public health · 2026Article
- Symptoms Experienced by Breast Cancer Patients Before, During and After Chemotherapy: A Systematic Review.International journal of women's health · 2026Review
- Acupuncture for cancer-related insomnia: An evidence mapping.Integrative medicine research · 2025Review
- Article
- Article
- Cancer-Related Fatigue, Psychological Symptoms, and Sleep Quality and Influencing Factors in Cancer Patients Receiving Chemotherapy.Inquiry : a journal of medical care organization, provision and financingArticle
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Authors and funding
9 authors.
Funding
Abstract
purposeThis study aims to assess effect of sleep disturbance, cancer-related fatigue, and depression on the quality of life (QoL) of breast cancer patients undergoing chemotherapy.
methodA descriptive, cross-sectional study was conducted at an oncology hospital in Cairo, Egypt, from November 2024 to February 2025. A total of 253 breast cancer patients undergoing chemotherapy were recruited through convenience sampling. Data were collected using validated instruments: Pittsburgh Sleep Quality Index (PSQI), Functional Assessment of Cancer Therapy-Breast (FACT-B), Cancer Fatigue Scale (CFS), and Patient Health Questionnaire-9 (PHQ-9) for depression. Linear regression models were employed to analyze the relationships between sleep disturbance, fatigue, depression, and QoL.
resultsFindings revealed that 99.2% of patients experienced fatigue, 87.4% reported poor sleep, and 93.3% exhibited depressive symptoms. Regression analysis demonstrated that sleep disturbance had the strongest negative impact on QoL (B = -1.506, p < 0.001), overshadowing both fatigue and depression. Correlation analysis further supported these findings, with sleep disturbance showing the highest negative correlation with QoL (r = -0.81, p < 0.001), followed by fatigue (r = -0.72, p < 0.001) and depression (r = -0.56, p < 0.001).
conclusionsSleep disturbance, cancer-related fatigue, and depression are significantly associated with reduced QoL in breast cancer patients undergoing chemotherapy. Among these factors, sleep disturbance appears to be the most influential. Interventions targeting sleep quality may help mitigate related psychological and physical challenges, thereby enhancing patients’ overall well-being.
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