ArticleBMC cancer2025
Genetically proxied therapeutic effect of antihypertensive drug use, breast cancer, and ovarian cancer's risk: a drug-target Mendelian randomization study.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundObservational studies have explored the association between antihypertensive drugs and the risk of breast cancer (BC) and ovarian cancer (OC). However, some controversy persists.
objectiveOur study aims to investigate the causal relationship between genetic proxies for antihypertensive drugs and breast and ovarian cancers using two-sample Mendelian randomization (MR) analysis.
methodsAnalyses were primarily conducted using the inverse variance weighted (IVW) method, with heterogeneity and horizontal pleiotropy tests, as well as sensitivity analysis, to assess the robustness of the results and the strength of the causal relationship.
resultsUsing the Bonferroni-corrected P-value as the threshold for testing causality (P < 0.0025), the MR analysis of systolic blood pressure as a biomarker in subset (A) (OR = 1.059, 95% CI: 1.024-1.096, P = 9.581 × 10
conclusionsOur study provides genetic evidence that CCBs increase the risk of OC, offering insight into the potential risks of pharmacological treatment with CCBs.
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