ArticleBMC ophthalmology2025
Analysis of choriocapillaris vascular density in patients with retinitis pigmentosa caused by RPGR gene mutations.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Genotype-phenotype correlations in retinitis pigmentosa: structural and vascular insights using OCT and OCTA.International journal of retina and vitreous · 2026Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAnatomic features characterizing the onset and progression of Retinitis Pigmentosa (RP) are still not clear and increasing interest has grown towards the impaired retinal flow in such disease. However, to date there are still few and inconsistent data exploring the changes reflected in vascular plexuses during the disease course, in particular regarding Choriocapillaris (CC). Therefore, the purpose of this study aimed at evaluating the CC perfusion in a cohort of males with RPGR-related X-Linked RP (XLRP).
methodsBest corrected visual acuity (BCVA), color fundus photograph, fundus autofluorescence (FAF), optical coherence tomography (OCT), OCT-angiography (OCTA) and microperimetry (MP) were performed in 13 XLRP patients (22 eyes) harboring mutations in RPGR. The percent perfused CC area (PPCA) was analyzed and correlated with the phenotypic variables and mutation location. Moreover, the PPCA of RPGR-related XLRP patients was compared with age-matched healthy controls.
resultsThe PPCA of the cases was 25.4% ± 7.5%, while controls displayed a PPCA of 32.3% ± 6.1% (p < 0.002). Moreover, PPCA appeared to be not significantly correlated with any of the anatomical and functional parameters analyzed, nor with the age of the patients, the duration of the disease and with the genotype.
conclusionsThe PPCA resulted significantly reduced in patients with RPGR-related XLRP when compared to age-matched healthy controls.
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