ArticleBMC cancer2025
The efficacy and safety of gemcitabine and docetaxel in pseudomyogenic hemangioendothelioma: a multi-center experience.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Pseudomyogenic hemangioendothelioma (involving skin, bone and soft tissue): a case report with long-term follow-up and review of literature.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Review
- Penile pseudomyogenic hemangioendothelioma: a rare case report with clinicopathologic features and multidisciplinary management.Frontiers in medicine · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundPseudomyogenic hemangioendothelioma (PHE) is a rare, locally aggressive vascular tumor. Less than 200 cases of PHE have been reported. Surgery is the cornerstone of PHE treatment, and the data on systemic treatment is limited.
methodsA retrospective multicenter study was conducted on patients with PHE between January 2016 to June 2024. The clinical characteristics were summarized and the efficacy and safety of the GD regimen (gemcitabine and docetaxel) were evaluated. The primary end point was progression-free survival (PFS). Secondary end points included overall survival (OS), objective response rate (ORR), disease control rate (DCR), and adverse events (AEs).
results16 patients were identified, with a male/female ratio of 7:1. The average age at diagnosis was 33 years. 43.8% of cases had multifocal lesions involved. The incidence of metastasis was higher than that of recurrence (43.8% vs. 18.8%). The median OS was not reached. 9 patients received chemotherapy. Among them, 6 patients were treated with GD and most of them (5/6, 83.3%) were palliative. In this palliative subgroup, 1-year PFS rate was 80.0% (4/5), with an ORR of 60% (3/5), and a DCR of 100% (5/5). Grade ≥ 3 AEs were reported in 3 patients, all classified as grade 3, without impacting the continuation of chemotherapy after symptomatic management.
conclusionsGemcitabine and docetaxel demonstrated satisfactory efficacy and acceptable safety in PHE patients; however, clinical trials and large-scale studies are needed to validate these results.
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