ArticleBMC pediatrics2025
Autism spectrum disorders and childhood caries: a comprehensive Mendelian randomization study.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Evaluation of oral health conditions among children with special health care needs using clinical records.Frontiers in public health · 2026Article
- Barriers to oral healthcare for autistic children in China.Frontiers in psychiatry · 2026Article
- Oral hygiene and caries experience in children with down syndrome and autism spectrum disorder: a systematic review and meta-analysis.Frontiers in dental medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to investigate the causal relationships between autism spectrum disorder (ASD) or pervasive developmental disorder (PDD) (excluding ASD and Asperger's syndrome [AS]) and childhood caries (primary teeth and permanent teeth).
methodsWe conducted two-sample Mendelian randomization (MR) analysis by utilizing summary-level data of ASD and PDD (excluding ASD and AS) as exposures, and childhood caries (primary teeth and permanent teeth) as outcomes.
resultsThe results showed that PDD (excluding ASD and AS) to be causally associated with caries in permanent teeth according to the inverse-variance weighted (IVW) (odds ratio [OR]: 1.151, 95%CI: 1.043-1.270, P = 0.005) and weighted median (OR: 1.159, 95%CI: 1.029-1.306, P = 0.015). However, according to the IVW (OR: 0.923, 95%CI: 0.873-1.003, P = 0.051), ASD might be causally associated with caries in permanent teeth. The results also showed no causal association between ASD or PDD (excluding ASD and AS) and caries in primary teeth.
conclusionsOur study showed PDD (excluding ASD and AS) to have pathogenic effects on childhood caries of permanent teeth among a population of European ancestry. However, ASD was shown to have protective effects on childhood caries of permanent teeth.
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