Evidence map›Paper›PMID 40597793›Full record

ArticleBMC cancer2025

Characteristic expression profile of small nucleolar RNAs and their association with tumor immune microenvironment in papillary thyroid carcinoma.

Qi-Lan Jiang, Fu-Yi Wang, Yuan Men, Yi-Huan Wu, Qin Xu, Yang Zeng, Jun Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cancers · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qi-Lan JiangDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China.
Fu-Yi WangDepartment of General Surgery (Thyroid Surgery), The Affiliated Hospital of Southwest Medical University, No.25 Taiping Street, Luzhou, Sichuan Province, China.
Yuan MenDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
Yi-Huan WuDepartment of Anesthesiology, Fujian Maternal and Child Health Hospital, Fuzhou, Fujian, China.
Qin XuDepartment of General Surgery (Thyroid Surgery), The Affiliated Hospital of Southwest Medical University, No.25 Taiping Street, Luzhou, Sichuan Province, China.
Yang ZengDepartment of Orthodontics, The Affiliated Stomatology Hospital of Southwest Medical University, No.2 Jiangyang Road, Jiangyang District, Luzhou, Sichuan Province, China. Zengyang826@swmu.edu.cn.
Jun JiangDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China. jiangjun@swmu.edu.cn.

Funding

Collaborative Research Program of Luzhou City and Southwest Medical University 2024LZXNYDJ019National Natural Science Foundation of China 82070288Sichuan Provincial Science and Technology Support Program 2022YFS0627
6 · The paper itself

Abstract

Certain cancers exhibit unique expression profiles of small nucleolar RNAs (snoRNAs), and the aberrant expression of snoRNAs may play significant roles in tumor biology. As the most common endocrine malignancy, the expression pattern and clinical relevance of snoRNAs in papillary thyroid carcinoma (PTC) remain largely unexplored. In this study, we employed small RNA microarray analysis to profile snoRNA expression in tumor tissues and corresponding normal thyroid tissues obtained from patients undergoing thyroidectomy. Differentially expressed snoRNAs (DE-snoRNAs) were validated by quantitative real-time PCR (qRT-PCR) and analysis of The Cancer Genome Atlas (TCGA) database. Furthermore, we applied CIBERSORTx and ESTIMATE algorithms to investigate the association between DE-snoRNA expression levels and clinicopathological features as well as tumor immune microenvironment in PTC. Our results revealed that SNORA68B, SNORA70F, and SNORD88A were downregulated in PTC tissues and potentially associated with the composition and distribution of tumor-infiltrating immune cells.

Indexed as

RNA, Small NucleolarThyroid Cancer, PapillaryThyroid NeoplasmsTumor MicroenvironmentAdultBiomarkers, TumorCarcinoma, PapillaryFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedBiomarkers, TumorRNA, Small NucleolarExpression profilePapillary thyroid carcinoma (PTC)Small nucleolar RNA (snoRNA)Tumor-infiltrating immune cells

Identifiers

PMID40597793
PMCPMC12211215

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.