Evidence map›Paper›PMID 40597752›Full record

ArticleBMC infectious diseases2025

Klebsiella predominance in peripancreatic microbial spectrum is associated with the severity of infected pancreatic necrosis.

Xiaolan Guo, Yao Xu, Kaiwei Li, Jingzhu Zhang, Zhihui Tong, Weiqin Li, Donghuang Hong

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In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xiaolan GuoDepartment of Critical Care Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, 134 Dongjie Street, Fuzhou, Gulou District, China.
Yao XuCenter of Severe Acute Pancreatitis, Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Kaiwei LiCenter of Severe Acute Pancreatitis, Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Jingzhu ZhangCenter of Severe Acute Pancreatitis, Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Zhihui TongCenter of Severe Acute Pancreatitis, Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Weiqin LiCenter of Severe Acute Pancreatitis, Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Donghuang HongDepartment of Critical Care Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, 134 Dongjie Street, Fuzhou, Gulou District, China. hongdh2003@fjmu.edu.cn.

Funding

the Natural Science Foundation of Fujian Province of China No. 2022J01404
6 · The paper itself

Abstract

backgroundInfectious pancreatic necrosis (IPN) is associated with the prognosis of acute pancreatitis (AP). The correlation between microbial diversity in the peripancreatic region and AP severity remains unclear. This study investigates whether pathogen profiles in peripancreatic necrosis differ between IPN patients with and without organ failure (OF), using 16 S ribosomal RNA (16 S rRNA) and internal transcribed spacer (ITS) sequencing.

methodsPatients with acute pancreatitis meeting clinical diagnostic criteria for IPN were prospectively enrolled. These patients were subsequently divided into an OF group and a non-OF group. Peripancreatic necrotic fluid samples were collected via percutaneous drainage and subjected to 16 S rRNA and ITS sequencing.

resultsA total of 28 patients with suspected infected pancreatic necrosis (IPN) were included, with 14 patients in the OF group and 14 in the non-OF group. No significant difference was observed in bacterial alpha diversity between the OF and non-OF groups. However, beta diversity showed significant differences according to Welch's t test (P < 0.001), Adonis analysis (P = 0.037) and Anosim analysis (P = 0.032). The relative abundance of Klebsiella significantly differed between the two groups (2.79% vs. 34.14%, P = 0.0093) and correlated with the length of hospital stay (r = 0.422, P = 0.025).

conclusionThe peripancreatic microbial profile is associated with the severity of acute pancreatitis, with Klebsiella being the dominant microflora in patients with IPN combined with OF.

Indexed as

KlebsiellaKlebsiella InfectionsPancreasPancreatitis, Acute NecrotizingAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesRNA, Ribosomal, 16SSeverity of Illness IndexRNA, Ribosomal, 16S16S ribosomal RNAAcute pancreatitisInfected pancreatic necrosisInternal transcribed spacer (ITS)

Identifiers

PMID40597752
PMCPMC12220423

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