ArticleBMC nephrology2025
Association between stress hyperglycemia ratio (SHR) and the risk of acute kidney injury in patients with chronic kidney disease: analysis of the MIMIC-IV database.
Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Integration of stress hyperglycemia ratio and c-reactive protein level improves postoperative acute kidney injury risk stratification after noncardiac surgery: A nested case-control study.Pakistan journal of medical sciences · 2026Article
- Association between stress hyperglycemia ratio and 28-day all-cause mortality in critically ill atrial fibrillation patients: a retrospective cohort study based on the MIMIC-IV database.Journal of thoracic disease · 2025Article
- Association of stress hyperglycemia ratio with mortality in sepsis-associated acute kidney injury: a retrospective analysis of the MIMIC-IV database.Scientific reports · 2025Article
- Correlation between stress hyperglycemic ratio and all-cause mortality in diabetic patients with heart failure.BMC endocrine disorders · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
backgroundStress hyperglycemia ratio (SHR) is a novel indicator used to evaluate the severity of SH. This study aimed to explore the association between SHR and the risk of AKI and death among individuals with chronic kidney disease (CKD).
methodsThis retrospective cohort investigation sourced data from the Medical Information Mart for Intensive Care-IV (MIMIC IV2.2) repository. The primary endpoint was AKI incidence, while secondary endpoints included in-hospital mortality and renal replacement therapy (RRT). The correlation of SHR with the likelihood of AKI in CKD patients was assessed utilizing restricted cubic spline (RCS) and Cox proportional hazards models. Then using Kaplan-Meier survival curves to analyze endpoint differences across varying SHR levels.
resultsAmong 2,500 CKD patients, 795 (31.8%) developed AKI during hospitalization. Cox proportional hazards analysis indicated a positive association between SHR and AKI incidence. The RCS model showed an approximately linear relationship, with higher SHR linked to increased AKI risk. In addition, Kaplan-Meier survival analysis unveiled notable distinctions in three endpoints across cohorts of patients characterized by varying SHR levels.
conclusionsSHR emerges as a dependable and autonomous indicator for predicting AKI occurrence and unfavorable renal outcomes in individuals with CKD. CLINICAL TRIAL NUMBER: Not applicable.
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