Evidence map›Paper›PMID 40597703›Full record

SynthesisBMC infectious diseases2025

Subacute thyroiditis as a post-COVID-19 complication: a systematic review.

Kiana Ghafourian, Fatemeh Salehian, Hosna Shakeri, Aidin Saadati, Sara Hatami, Mehdi Goudarzi, Rosella Centis, Lia D'Ambrosio, Giovanni Sotgiu, Mohammad Javad Nasiri and 1 more

Abstract readSystematic Review
In one paragraph

Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kiana GhafourianResearch Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fatemeh SalehianResearch Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hosna ShakeriResearch Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Aidin SaadatiResearch Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sara HatamiResearch Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehdi GoudarziDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rosella CentisServizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy.
Lia D'AmbrosioPublic Health Consulting Group, Lugano, Switzerland.
Giovanni SotgiuClinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy. gsotgiu@uniss.it.
Mohammad Javad NasiriDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mj.nasiri@hotmail.com.
Giovanni Battista MiglioriServizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy. giovannibattista.migliori@icsmaugeri.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe emergence of Subacute Thyroiditis (SAT) in the wake of COVID-19 has presented a unique set of challenges for clinicians and researchers. This study delves into the intricate interplay between COVID-19 and SAT, examining a wealth of cases from observational studies.

methodsWe conducted a comprehensive literature review utilizing PubMed/MEDLINE, EMBASE, and Scopus databases, encompassing studies available up to January 2, 2025. The search strategy incorporated a combination of keywords such as "Subacute Thyroiditis" and "COVID-19," complemented by synonyms and Mesh terms. Relevant studies, investigating COVID-19-associated SAT were included.

resultsAfter a meticulous review of 964 papers, 46 records were included in the final analysis, consisting of 37 case reports and 9 case series. Our study, covered 75 individuals aged 18 to 85. Investigated patients presenting diverse symptoms, including anterior cervical pain and palpitations, displaying varying timelines from COVID-19 onset to SAT symptoms. Treatment approaches, involving prednisone and non-steroidal anti-inflammatory drugs (NSAIDs), led to recovery in many cases, but some individuals experienced a transition to hypothyroidism. The diagnostic and laboratory investigations across revealed diverse profiles, thyroid imaging findings, inflammatory markers, thyroid function tests, and the presence of anti-thyroid antibodies.

conclusionThe complexity of SAT is emphasized, particularly in the context of COVID-19. The consistent trend toward recovery of thyroid function not only suggests potential treatment efficacy but also emphasizes the necessity for vigilant symptom monitoring, especially in individuals with a history of COVID-19. Future studies should further investigate the details of SAT post-COVID-19, improving approaches to diagnosis, treatment, and patient care.

Indexed as

COVID-19Thyroiditis, SubacuteAdolescentAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedSARS-CoV-2Young AdultCOVID-19Subacute thyroiditisSystematic review

Identifiers

PMID40597703
PMCPMC12220452

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.