SynthesisBMC gastroenterology2025
Correlation between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with prognosis in gastric cancer patients undergoing neoadjuvant chemotherapy: a meta-analysis.
Synthesis in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Short- and long-term outcomes of conversion surgery for gastric cancer with massive peritoneal metastasis: a single-center retrospective study.Surgery today · 2026Article
- Dynamic machine learning model integrating resting energy expenditure for predicting postoperative complications after gastrectomy for gastric cancer.Journal of cancer research and clinical oncology · 2026Article
- The CALLY index as a comprehensive inflammation-nutrition-immunity marker for prognosis in gastric cancer surgery.Surgical endoscopy · 2026Article
- Article
- Pretreatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as prognostic biomarkers for neuroblastoma risk stratification.Frontiers in immunology · 2026Article
- The role of peripheral blood cell analysis-derived inflammatory parameters in predicting malignant duodenal stenosis.BMC gastroenterology · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with poorer prognosis of gastric cancer (GC) patients and may guide treatment decisions. This meta-analysis aims to evaluate the impact of NLR and PLR on the prognosis of GC patients undergoing neoadjuvant chemotherapy (NAC).
methodsCochrane, Embase, PubMed and Web of science were searched for studies up to November 30, 2024. Meta-analysis was conducted to evaluate the pooled effect. Sensitivity analysis was conducted by removing a different study each time. Publication bias was assessed by Egger’s test and Begg’s test to evaluate quantitatively.
resultsA total of 16 studies were included in this meta-analysis from 3,094 studies. Pre-NAC high NLR level was associated with poorer overall survival outcomes (HR = 1.96, 95% CI 1.21–3.20). Similarly, post-NAC high NLR was also correlated with worse overall survival outcomes (HR = 1.69, 95% CI 1.04–2.76). However, pre-NAC PLR and post-NAC PLR did not appear to exhibit a significant correlation with the prognosis of gastric cancer patients following NAC.
conclusionNLR is emerging as a potential prognostic indicator for gastric cancer, particularly in patients receiving NAC. Elevated NLR levels both before and after NAC are associated with poorer overall survival outcomes in gastric cancer patients.
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