Evidence map›Paper›PMID 40597682›Full record

ArticleBMC microbiology2025

Nosocomial transmission, adaption and clinical outcomes of carbapenem-resistant hypervirulent Klebsiella pneumoniae.

Yanjun Liu, Zhiqian Wang, Zijuan Jian, Peilin Liu, Yanming Li, Fang Qin, Qun Yan, Wenen Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanjun LiuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhiqian WangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zijuan JianDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Peilin LiuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yanming LiDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Fang QinDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qun YanDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wenen LiuDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China. wenenliu@163.com.

Funding

National Key Research and Development Program of China 2018YFC2000203
6 · The paper itself

Abstract

backgroundCarbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKp) poses a significant threat in healthcare settings. This study investigates the nosocomial transmission dynamics, adaptive phenotypes, and clinical outcomes of CR-HvKp with different evolutionary patterns.

methodsA genomic analysis of 2,002 Klebsiella pneumoniae isolates collected from a major teaching hospital in China was performed to identify convergent isolates. Epidemiological features, including CR-HvKp nosocomial transmission, were assessed. Selected isolates underwent phenotypic testing to evaluate adaptive traits. Clinical outcomes were analyzed retrospectively using electronic medical records.

resultsA total of 127 CR-HvKp were characterized, with ST11-KL64 hv-CRKP (carbapenem resistant Klebsiella pneumoniae acquired hypervirulence) as the predominant sequence type. CR-HvKp exhibited diverse evolutionary patterns linked to nosocomial transmission, particularly in the ICU. ST11-KL64 hv-CRKP demonstrated robust transmission within ICU settings. Compared to CRKP, hv-CRKP showed enhanced in vitro competitiveness and superior immune evasion. CR-HvKp infections were significantly associated with higher mortality rates, especially involved in sepsis or septic shock (P < 0.0001).

conclusionThe ST11-KL64 hv-CRKP clonal complex is highly prevalent in CR-HvKp and demonstrates significant nosocomial transmission, particularly within ICU settings. Timely and effective sepsis management is critical to improving survival outcomes in CR-HvKp infections. Continuous genomic surveillance is imperative to control the spread of these pathogens.

Indexed as

Carbapenem-Resistant EnterobacteriaceaeCarbapenemsCross InfectionKlebsiella InfectionsKlebsiella pneumoniaeAgedAnti-Bacterial AgentsChinaFemaleHumansIntensive Care UnitsMaleMicrobial Sensitivity TestsMiddle AgedRetrospective StudiesVirulenceAnti-Bacterial AgentsCarbapenemsAdaptationCarbapenem-resistant hypervirulent Klebsiella pneumoniaeClinical outcomesEvolutionary patternsNosocomial transmission

Identifiers

PMID40597682
PMCPMC12219914

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.