ArticleBMC microbiology2025
Comparative microbiome analysis of contracted breast capsules: a cross-sectional study.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Pilot Study: Vancomycin Calcium Sulfate Beads in the Prevention of Recurrent Capsular Contracture of Breast Implants.Plastic and reconstructive surgery. Global open · 2026Article
- Capsular Contracture in Implant-Based Breast Reconstruction: A Comprehensive Narrative Review of Pathophysiology, Risk Factors, and Contemporary Controversies.Medicina (Kaunas, Lithuania) · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the implication of bacterial biofilms in the etiology of capsular contracture, there is limited research on the microbial structure of the contracted capsule. Moreover, the potential role of the skin microbiome in capsular contracture remains undefined. Therefore, we conducted this study to characterize the microbiome of the breast capsular contracture by comparing it with the microbiome of biopsy without capsular contracture. We also investigated the associations between the microbial structures of the skin surrounding the breast and those of the breast capsule.
resultsWe collected 25 capsules, including 14 samples without capsular contracture and 11 samples with capsular contracture. Beta diversity analysis demonstrated that the microbial structures in the breast capsules were distinctly different from those in the skin. The capsular microbiota was more influenced by individual variation than by the progression of the capsular contracture. Breast capsules with capsular contracture showed a higher relative abundance of Staphylococcus, correlating positively with total bacterial load.
conclusionsCapsular contracture is associated with an escalation in total bacterial load and an increase in the abundance of opportunistic pathogens, such as Staphylococcus. This comparative analysis of contracted breast capsules emphasizes the management of pathogens, considering bacterial load, in the occurrence of capsular contracture.
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