Evidence map›Paper›PMID 40597677›Full record

ArticleBMC gastroenterology2025

Genetic mechanism of β-alanine metabolic pathway affecting colorectal cancer prognosis.

Tingyu Zhao, Yali Jiang, Qi Liang, Sumeng Wang, Xiao Zhang, Siqi Ni, Yi Jiao, Lingxiang Liu

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Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tingyu Zhao *Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Yali Jiang *Department of Oncology, The Friendship Hospital of Ili Kazakh Autonomous Prefecture, Chongqing Road 58 th, Yining, 835000, Xinjiang Uygur Autonomous Regio, China.
Qi LiangDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Sumeng WangDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Xiao Zhang *Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Siqi NiDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Yi JiaoDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Lingxiang LiuDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. llxlau@163.com.

Funding

Research Fund of Yili Institute of Clinical Medicine yl2021ms02
6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) is a common cause of cancer-related mortality and is mainly influenced by metabolic dysfunction. The β-alanine metabolic pathway plays an important role in altering the aggressiveness and metabolic characteristics of the cancer cells. This study aimed to investigate the genetic role of the β-alanine metabolic pathway in CRC patient survival.

methodsUsing a Cox regression model, we assessed the impact of 27 single-nucleotide polymorphisms (SNPs) from 31 genes in the β-alanine metabolic pathway on overall survival (OS) and progression-free survival (PFS) in 287 patients with CRC. Additional methods, including differential expression analysis, expression quantitative trait loci analysis, dual-luciferase reporter assay, and cell phenotype assay, were used to evaluate the genetic function of candidate SNPs in tumor progression.

resultsWe identified that SNP rs2811182 A > G allele located in DPYD was significantly associated with poorer prognosis of CRC, with hazard ratio (HR) of 0.63 for OS [95% confidence interval (CI) = 0.45-0.88, P = 7.12 × 10

conclusionsThis study indicates a pivotal genetic role for the β-alanine metabolic pathway, particularly rs2811182 in DPYD, in influencing CRC prognosis. These findings offer new perspectives for personalized treatment strategies and enhance our understanding of CRC pathogenesis.

Indexed as

beta-AlanineColorectal NeoplasmsAgedCell Line, TumorFemaleHumansMaleMetabolic Networks and PathwaysMiddle AgedPolymorphism, Single NucleotidePrognosisProgression-Free SurvivalProportional Hazards Modelsbeta-AlanineBeta-alanine metabolismColorectal cancerPrognosisSingle-nucleotide polymorphisms

Identifiers

PMID40597677
PMCPMC12210834

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.