Trial reportBMC anesthesiology2025
Intraoperative titration of positive end-expiratory pressure in urological patients undergoing laparoscopic procedures under lateral position: a randomized controlled trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-drug perioperative interventions to reduce postoperative pulmonary complications after abdominal surgery: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2026Pooled it
- Thoracic electrical impedance tomography from technological promise to clinical reality: the Chinese experience.Journal of thoracic disease · 2026Review
- EIT-guided end-expiratory pressure individualization in robotic surgery with high PEEP ventilation: a prospective observational study.BMC anesthesiology · 2026Article
- Recent advances in experimental and clinical applications of chest electrical impedance tomography: a narrative review.Intensive care medicine experimental · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveThe study aimed to investigate the role of electrical impedance tomography (EIT)-guided individualized positive end-expiratory pressure (PEEP) in surgical patients under lateral position.
methodsThe urological patients undergoing elective laparoscopic surgery were randomly allocated to either the PEEPEIT (titrated with EIT) or PEEP5 (fixed PEEP = 5cmH₂O) groups. The PEEP titration protocol commenced at 3 cmH₂O, with increments of 2 cmH₂O every 2 min until reaching 17 cmH₂O. Once the EIT-titrated optimal PEEP level was determined with minimized regional overdistension and collapse, it was maintained until the end of surgery. The PaO₂/FiO₂ ratio, respiratory mechanics parameters and hemodynamic parameters were recorded at 5 min before anesthesia induction (T0), 5 min after PEEP setting (T1), at the end of surgery (T2), and 30 min after extubation (T3).
resultsA total of 46 subjects were randomized. The median PEEP was 13 cmH2O [25th − 75th percentiles, 11–14 cmH2O] in the PEEPEIT group. The PEEPEIT group had higher PaO2/FiO2 ratio (423.2 ± 42.2 vs. 349.7 ± 48.0, P<0.001) before extubation compared with the PEEP5 group. Further, PEEPEIT group had higher plateau pressure and dynamic compliance, while lower driving pressure at both T1 (all P < 0.05) and T2 (P < 0.05) time points. Hemodynamic changes were similar in two groups (P > 0.05). There was no significant statistical difference in PaO2/FiO2 ratio at 30 min after extubation between the two groups (379.7 ± 38.2 vs. 381.6 ± 54.0, P = 0.896).
conclusionEmploying an EIT-guided individualized PEEP level during the surgery under lateral position may improve the pulmonary ventilation and respiratory mechanics, potentially improving oxygenation. However, this improved oxygenation seems not to be maintained after extubation.
trial registrationChina Clinical Trial Registration Center Identifier ChiCTR2100053895. Registered 02/12/2021.
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