ArticleBMC gastroenterology2025
TyG-BMI as a superior predictor of MAFLD and pre-MAFLD in Chinese adults: a cross-sectional study.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- The association of triglyceride-glucose index and uric acid-high-density lipoprotein cholesterol ratio with the risk of uterine fibroids: a real-world analysis based on health examination data.Journal of health, population, and nutrition · 2026Article
- Anthropometry-adjusted TyG indices improve insulin resistance estimation: an exploratory euglycemic-hyperinsulinemic clamp study in Japanese adults without diabetes.Diabetology international · 2026Article
- The association of TyG-BMI with MAFLD and liver fibrosis: a cross-sectional study.Scientific reports · 2026Article
- Diagnostic performance of TyG-related indices for MAFLD screening in older adults at moderate altitude: TyG-BMI showed the highest discriminatory ability.BMC gastroenterology · 2026Article
- Body Mass Index Outperforms Triglyceride-Glucose Index in Predicting MAFLD in Type 2 Diabetes: A Cross-Sectional Mediation and Interaction Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Adiposity and Metabolic Indices in the Diagnosis and Histological Stage Association of Metabolic Dysfunction-Associated Steatotic Liver Disease.Journal of clinical medicine · 2025Article
- Analysis of risk factors associated with metabolic-associated fatty liver disease from Suzhong Region, China: a cross-sectional study.BMJ open · 2025Article
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9 authors.
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Abstract
backgroundMetabolic-associated fatty liver disease (MAFLD), a highly prevalent global liver disorder, requires early diagnosis and treatment to delay progression, yet lacks simple diagnostic tools. We aimed to evaluate the validity of the triglyceride-glucose index (TyG) and its related indexes in predicting MAFLD and pre-MAFLD among Chinese individuals.
methodsThis cross-sectional study enrolled 9,627 Chinese participants (mean age 46.53 ± 11.87 years; 62.1% males) categorized into three groups based on MAFLD diagnostic criteria. Baseline characteristics were analyzed using one-way ANOVA and Kruskal-Wallis tests. To evaluate independent associations, we performed logistic regression analyses of anthropometric markers and TyG-related indexes with MAFLD status. Furthermore, the dose-response relationship between the TyG and related indexes and MAFLD risk was examined using restricted cubic splines (RCS). Finally, receiver operating characteristic (ROC) curve analysis quantified the predictive performance of each index for MAFLD and pre-MAFLD.
resultsMean blood pressure, anthropometric indicators, and median TyG index and related parameters were significantly higher in the MAFLD group compared to the non-MAFLD group (p <.001). The pre-MAFLD group exhibited intermediate metabolic values between the non-MAFLD and MAFLD groups. Logistic regression analyses revealed anthropometric indicators, TyG index and related indicators were independent risk factors for MAFLD, adjusted for age, gender, blood pressure, blood glucose, and liver function markers. RCS analyses showed a nonlinear positive association between TyG index and related indexes and MAFLD risk (p for nonlinear <.0001). TyG-BMI demonstrated the highest area under the curve (AUC) for both MAFLD (0.874, 95%CI 0.867-0.881) and pre-MAFLD (0.823, 95%CI 0.810-0.836), with optimal cutoffs of 217.41 and 202.54, respectively.
conclusionsTyG-related indices, particularly TyG-BMI, showed superior discriminative ability for MAFLD and pre-MAFLD compared to traditional anthropometric measures in this Yangtze River Delta population, demonstrating an S-shaped dose-response relationship with MAFLD risk. These findings support TyG-BMI as a potential first-line screening tool.
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