ArticleBMC genomics2025
Comprehensive transcriptome analysis reveals MSTRG.19853.1/ssc-miR-361-3p/NPPA axis is related to hypoxic adaptation in Tibetan pigs.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- circRNA-Associated ceRNA Regulatory Networks in Cardiac Responses to High-Altitude Hypoxia in Tibetan Pigs (International journal of molecular sciences · 2026Article
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6 authors.
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Abstract
backgroundThe Tibetan pig, an indigenous breed adapted to plateau environments in China, exhibits remarkable tolerance to extreme high-altitude conditions. Recent studies have highlighted the pivotal role of non-coding RNAs (ncRNAs) in regulating hypoxic adaptation. However, the complex regulatory network involving mRNAs and ncRNAs that mediate this adaptation in Tibetan pigs remains poorly understood.
resultsWe performed whole-transcriptome sequencing to analyze expression profiles of mRNAs, lncRNAs, and miRNAs in heart tissues of Tibetan pigs (TH) and Yorkshire pigs (YH) at high altitude. We identified 795 differentially expressed lncRNAs (DE lncRNAs), 149 differentially expressed miRNAs (DE miRNAs), and 2,206 differentially expressed mRNAs (DE mRNAs) between TH and YH. Functional enrichment analysis showed that target genes of DE miRNAs, DE lncRNAs, and DE mRNAs significantly enriched pathways related to hypoxic adaptation, including Dilated Cardiomyopathy (DCM) and Hypertrophic Cardiomyopathy (HCM). We constructed a competing endogenous RNA (ceRNA) regulatory network comprising 8 DE lncRNAs, 37 DE miRNAs, and 7 DE mRNAs. Notably, we validated the MSTRG.19853.1/ssc-miR-361-3p/NPPA axis, a candidate regulator of cardiac adaptation, using quantitative real-time PCR (qRT-PCR) and dual-luciferase reporter assays.
conclusionOur findings elucidate comprehensive RNA expression profiles and ncRNA-mRNA interactions underlying hypoxic adaptation in Tibetan pig hearts compared to Yorkshire pigs at high altitude. The MSTRG.19853.1/ssc-miR-361-3p/NPPA axis represents a promising candidate for regulating cardiac adaptation under hypoxia, pending in vivo validation. These insights enhance our understanding of the genetic mechanisms driving high-altitude adaptation in Tibetan pigs, offering a foundation for comparative studies of hypoxic resilience in plateau mammals.
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