SynthesisBMC anesthesiology2025
The clinical significance of thrombocytopenia in sepsis and septic shock: a systematic review and meta-analysis.
Synthesis in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Early prophylactic anticoagulation in patients with severe sepsis-associated thrombocytopenia: a target trial emulation.Journal of thrombosis and thrombolysis · 2026Article
- Prognostic impact of platelet count trajectories in acute decompensated heart failure: a retrospective cohort analysis.BMC cardiovascular disorders · 2026Article
- [Association of platelets with multiple organic failure in septic patients].Revista medica del Instituto Mexicano del Seguro Social · 2026Observational
- Platelet Recovery and Mortality in Septic Patients with Thrombocytopenia: A Propensity Score-Matched Analysis of the MIMIC-IV Database.Journal of clinical medicine · 2026Article
- Risk stratification and determinant identification of high-need, high-cost ICU patients using machine learning: a large-scale retrospective study from a multi-specialty ICU in a tertiary hospital.Frontiers in public health · 2026Article
- Clinical characteristics of pyogenic liver abscess patients with multiple organ dysfunction syndrome and development and validation of a predictive model.Frontiers in cellular and infection microbiology · 2026Article
- A single-center study on epidemiology, microbial distribution, and mortality predictors in catheter-related bloodstream infections.BMC infectious diseases · 2025Article
- Platelet factor 4 modulates endothelial cell antimicrobial activity to enhance bacterial clearance and improve sepsis outcomes.bioRxiv : the preprint server for biology · 2025Article
- Avatrombopag and Platelet Recovery in Sepsis-Associated Thrombocytopenia: A Retrospective Observational Cohort Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisObservational
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7 authors.
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Abstract
backgroundThrombocytopenia (TCP) is a common finding in critically ill patients that has been linked to a worse prognosis. Specifically, sepsis is a major risk factor for TCP. Several observational studies have examined the prognostic role of TCP and its correlation with clinical outcomes in patients with sepsis.
methodsWe conducted a systematic search through Medline, Scopus and CENTRAL, from inception until June 2024, in order to identify studies that discussed the effects of TCP on clinical outcomes in patients with sepsis or septic shock. This review was performed in accordance with the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines. Study endpoints were ICU mortality, 28-day mortality, major bleeding and mechanical ventilation.
resultsWe included twelve studies enrolling 14,093 patients in this meta-analysis. TCP was diagnosed at intensive care unit (ICU) admission in 5481 (39%) patients; on the other hand, it was encountered during the course of ICU stay in 1474 (10%) cases. Patients with TCP had significantly higher risks of ICU mortality (Odds Ratio: 1.93, 95% CI [1.6-2.33]; p < 0.01). and 28-day mortality (odds ratio: 1.98, 95% CI [1.67, 2.35]; p < 0.00001). Furthermore, patients with severe TCP (platelet count < 50 * 10
conclusionTCP exhibits significant clinical implications in critically ill patients admitted with sepsis and is associated with enhanced mortality and worse clinical outcomes. Nonetheless, this meta-analysis quantifies the significant association between TCP and poor clinical outcomes in patients with sepsis and septic shock.
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