SynthesisBMC anesthesiology2025
Comparison of the effects of remimazolam and propofol on postoperative delirium in elderly surgical patients: a meta-analysis.
Synthesis in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of remimazolam on postoperative neurocognitive disorder in elderly surgical patients: a systematic review and meta-analysis.Frontiers in pharmacology · 2026Pooled it
- Effects of remimazolam vs. propofol on plasma neurofilament light chain and postoperative delirium in frail elderly patients undergoing major non-cardiac surgery: a prospective, randomized, assessor-blinded controlled trial.BMC anesthesiology · 2026Trial
- Remimazolam Versus Propofol for General Anesthesia in Older Adults Undergoing Colon Cancer Surgery: A Systematic Review and Meta-Analysis of Comparative Studies.Pharmaceutics · 2026Review
- Effect of Remimazolam on Postoperative Delirium in Elderly Surgical Patients: A Critical Review of Pharmacological Mechanisms and Clinical Evidence.Drug design, development and therapy · 2026Review
- The 90% effective dose of remimazolam in combination with sufentanil for sedation in patients undergoing gastroscopy.Frontiers in medicine · 2026Article
- Effects of different sedation regimens on delirium in ICU patients.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveThis meta-analysis evaluated the effectiveness of remimazolam compared to propofol in preventing postoperative delirium among elderly surgical patients.
methodsWe systematically searched PubMed, CNKI, Cochrane Library, Web of Science, Embase, Wangfang, and VIP for randomized controlled trials (RCTs) comparing remimazolam and propofol for postoperative delirium prevention in elderly surgical patients (last search: July 27, 2024). Data were analyzed using Stata 15.0.
resultsEight randomized controlled trials (2,013 participants; remimazolam = 1,034, propofol = 979) found no significant differences in postoperative delirium incidence [RR = 0.67,95%CI(0.45–1.01)], severity [WMD=-0.28,95%CI(-0.61-0.04)], or duration [WMD=-0.06,95%CI(-0.15-0.03)], nor in postoperative pain VAS scores [WMD=-0.08,95%CI(-0.18-0.02)]. remimazolam significantly reduced postoperative hypotension risk compared to propofol [RR = 0.48,95%CI(0.29–0.80)], demonstrating improved safety.
conclusionThis meta-analysis demonstrates comparable efficacy between remimazolam and propofol in preventing postoperative delirium, with remimazolam demonstrating superior safety through significantly lower postoperative hypotension rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.