Trial reportBMC anesthesiology2025
Effects of Intranasal dexmedetomidine and esketamine for premedication on postoperative pain after tonsillectomy and adenoidectomy in children: a randomized clinical trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Safety of Dexmedetomidine-Esketamine Versus Dexmedetomidine Alone as Premedication for Pediatric Anesthesia Induction: A Systematic Review, Meta-Analysis, and Trial Sequential Analysis.Paediatric anaesthesia · 2026Pooled it
- Preoperative sedation with intravenous S-ketamine versus midazolam in preschool children: a randomized controlled trial.BMC anesthesiology · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative acute pain is a common issue in children after surgery. Our study aimed to investigate whether preoperative use of a dexmedetomidine-esketamine combination could reduce postoperative pain in children undergoing tonsillectomy and adenoidectomy and reduce side effects, such as bradycardia, hypotension or emergence delirium.
methodsIn this double-blind, randomised controlled clinical trial, 180 children were randomly assigned to 3 groups. 30 min before surgery, the control group received 0.9% saline intranasally (Group C), the dexmedetomidine group received intranasal dexmedetomidine at 2.0 μg·kg
resultsA total of 173 children completed the study. The AUC of the pain score at rest within 24 h after surgery was 37.25 (20.25-51.75) in Group C, which was higher than those in Groups D (19.25 [12.50-39.13], P < 0.001) and DS (9.50 [9.00-16.25], P < 0.001). Compared with the control group, the DS group had a lower incidence of ED (12.3% vs. 44.8%, P = 0.001). Heart rates (HRs) in groups DS (P < 0.001) and C (P < 0.001) were higher than those in the dexmedetomidine group at all time points. No serious adverse events occurred.
conclusionsIntranasal dexmedetomidine combined with esketamine for premedication was associated with reduced postoperative pain in children. It can also prevent ED and had fewer side effects.
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