ArticleAnnals of medicine2025
MASS-4 is more suitable than MASS-3 for prognostic stratification in transplant-eligible patients with newly diagnosed multiple myeloma.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mass spectrometry-based proteomics and metabolomics in multiple myeloma: a systematic review of prognostic biomarkers and minimal residual disease monitoring.Frontiers in medicine · 2026Pooled it
- Real-world clinical outcomes of autologous stem cell transplantation in Chinese patients with newly diagnosed multiple myeloma: a systematic literature review.Therapeutic advances in hematology · 2026Review
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7 authors.
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Abstract
objectivesReal-world studies have shown that Mayo Additive Staging System (MASS) -3 and MASS-4 are suitable for prognostic stratification in Chinese patients with newly diagnosed multiple myeloma (NDMM), but there is no clear evidence of their utility in transplant-eligible NDMM patients. We aimed to evaluate and compare the prognostic stratification value of MASS-3 and MASS-4 in transplant-eligible patients with NDMM in China. PATIENTS AND
methodsA retrospective analysis of the clinical data of 215 NDMM patients who received 'induction therapy-autologous hematopoietic stem cell transplantation (ASCT)' in our center from 2013 to 2022 was performed. The prognostic stratification value of the two staging techniques was compared in terms of patient's overall survival (OS) and progression free survival (PFS), using different transplant times, different ages, and different induction regimens.
resultsThe median progression-free survival (PFS) was 99, 88, and 51 months (
conclusionsAmong transplant-eligible patients with NDMM, the prognostic stratification value of MASS-4 was better than that of MASS-3, particularly distinguishing high-risk patients with poor prognosis. Compared with single ASCT, tandem ASCT may overcome the poor prognosis of high-risk MASS patients.
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