ReviewInternational journal of emergency medicine2025
Neuron-specific enolase: a potential biomarker in the prediction of pediatric head trauma outcomes: a systematic review and meta-analysis.
Review in International journal of emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
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Abstract
backgroundTraumatic brain injury (TBI) is the most common type of brain injury and significantly contributes to morbidity and mortality in both adults and children. Diagnosing pediatric head trauma with precision is difficult, particularly for youngsters displaying mild symptoms. Contemporary research has investigated the capacity of biomarkers, including neuron-specific enolase (NSE), to enhance the precision of diagnosis.
objectiveThe objective of this systematic review and meta-analysis was to assess the levels of NSE in pediatrics with head trauma.
methodsA comprehensive literature search was performed among PubMed, Scopus, and Embase databases, from the inception to August 17
resultsFollowing the screening and eligibility validation process, 12 studies were selected, which evaluated 806 participants. Meta-analyses revealed markedly elevated NSE levels in patients as compared to controls (p-value < 0.001), indicating its potential as a biomarker for head injury. Further subgroup analyses demonstrated more pronounced correlations between increased NSE levels and severe trauma (p-value < 0.001). In addition, cerebrospinal fluid samples had significantly higher NSE levels than other sample origins (p-value < 0.001). Elevated levels of NSE were also associated with unfavorable results, as assessed by the Glasgow Outcome Scale (p-value < 0.001).
conclusionThe findings emphasize the capacity of NSE as a diagnostic and predictive instrument for pediatric head injury, justifying additional research into its clinical uses.
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