ArticleInternational journal of retina and vitreous2025
The impact of epiretinal membrane stage and postoperative treatment on visual and anatomical outcomes following vitrectomy in eyes with preexisting macular edema.
Article in International journal of retina and vitreous, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Retinal glial cell removing during internal limiting membrane peeling is associated with higher-stage idiopathic epiretinal membrane.Eye and vision (London, England) · 2026Article
- Predictors of two-year visual outcomes after surgery for stage 3-4 epiretinal membrane: role of baseline vision and early retinal microstructural recovery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Extended Depth of Field Intraocular Lens for Cataract After Vitrectomy for Retinal Detachment: A Prospective Trial.Ophthalmology and therapy · 2026Article
- Immunohistochemical clinicopathologic correlation and OCT analysis of idiopathic and secondary epiretinal membrane specimens.International journal of ophthalmology · 2026Article
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Authors and funding
7 authors.
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Abstract
backroundIdiopathic epiretinal membrane (iERM) is often associated with different types of macular edema (ME). This study aimed to evaluate the impact of iERM stage and postoperative treatment on visual and anatomical outcomes after pars plana vitrectomy (PPV) with peeling in eyes with iERM and treatment-naïve pre-existing ME.
methodsThis retrospective analysis included eyes with iERM and different preexisting ME (microcystic = MME, cystoid = CME or combined ME) that underwent PPV with iERM and ILM-peeling and were followed for 12 months. Various OCT parameters, including central foveal thickness (CRT), outer nuclear layer (ONL) thickness, ectopic inner foveal layer (EIFL) thickness, presence of subretinal fluid, ellipsoid zone defects and central bouquet abnormalities were evaluated for their correlation with visual outcomes. Standard escalating postoperative treatment was steroids, adjuvant non-steroidal anti-inflammatory eye drops, adjuvant parabulbous injection (40 mg triamcinolone), intravitreal injection of long-lasting dexamethasone implant.
resultsFifty eyes of 50 patients with iERM (stages 2-4) and MME (n = 20), CME (n = 15) or combined ME (n = 15) were included. Baseline BCVA was better in lower iERM stages (p = 0.011), showed no significant differences at 12 months (p = 0.379) and depended on underlying ME (p < 0.001). Worse final BCVA was associated with older age (Odds ratio [OR], 1.292; p = 0.001), need for treatment with intravitreal injection according to the standard escalating treatment schema (OR: 1.230; p = 0.007), preoperative EIFL > 100 μm (OR: 1.305; p < 0.001) and preoperative CRT < 450 μm (OR: 1.164; p = 0.048).
conclusionsBaseline BCVA varied depending on pre-existing ME and iERM stage. Final BCVA was similar across all iERM stages but poorer in eyes with combined ME. Older age, preoperative EIFL > 100 μm, and need for treatment with intravitreal injection were associated with worse final BCVA.
trial registrationThe study was approved by the Institutional Review Board and the Ethics Committee of the Ludwig-Maximilian-University, Munich (Ethics Votum: 19/624) and adhered to the tenets of the Declaration of Helsinki.
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