Evidence map›Paper›PMID 40597416›Full record

ArticleExperimental physiology2025

Individuals with persisting post-concussion symptoms with physiological subtype demonstrate altered cardiovascular and autonomic responses to face cooling.

Phillip J Wallace, Steve Lidstone, Josh G Nowlan, Johnathan Ljubanovich, Brandon J McKinlay, Stephen A Klassen, Stephen S Cheung

Abstract read
In one paragraph

Article in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Phillip J WallaceDepartment of Kinesiology, Brock University, St Catharines, Ontario, Canada.ORCID https://orcid.org/0009-0006-7023-3856
Steve LidstoneBrock University Sports Performance & Sports Medicine, Brock University, St Catharines, Ontario, Canada.
Josh G NowlanDepartment of Kinesiology, Brock University, St Catharines, Ontario, Canada.
Johnathan LjubanovichDepartment of Kinesiology, Brock University, St Catharines, Ontario, Canada.
Brandon J McKinlayFaculty of Applied Health & Community Sciences, Sheridan College, Brampton, Ontario, Canada.
Stephen A KlassenDepartment of Kinesiology, Brock University, St Catharines, Ontario, Canada.ORCID https://orcid.org/0000-0002-4560-8728
Stephen S CheungDepartment of Kinesiology, Brock University, St Catharines, Ontario, Canada.ORCID https://orcid.org/0000-0002-6149-4978

Funding

Brock University AIF-2021Canadian GovernmentNatural Sciences and Engineering Research Council of Canada (NSERC) 2018-04077
6 · The paper itself

Abstract

Individuals with persisting post-concussion symptoms with physiological subtype (PPCS-P) demonstrate exercise intolerance due to exacerbation of concussion-like symptoms during incremental exercise. We tested the hypothesis that individuals with PPCS-P (n = 12) would have a blunted cardiac autonomic response to face cooling compared to healthy controls (CTRL, n = 12). Participants were supine and performed a 5 min baseline, then experienced a 3 min face cold pressor test followed by 5 min of recovery. A three-lead electrocardiogram was used to measure heart rate and root mean square of successive differences in R-R intervals (RMSSD), finger photoplethysmography was used to measure mean arterial pressure (MAP), and laser-Doppler flowmetry was used to measure finger skin blood flux. The PPCS-P group had a lower exercise tolerance (9.9 ± 3.2 min, P < 0.001) and lower peak heart rate (170.0 ± 14.0 beats·min

Indexed as

autonomic nervous system functionexercise intoleranceface cold pressor testpersisting post‐concussion symptomspersisting symptoms after concussion

Identifiers

PMID40597416
PMCPMC13394944

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.