ReviewOrphanet journal of rare diseases2025
Research trends and hotspots of adult Alagille syndrome: a bibliometric analysis.
Review in Orphanet journal of rare diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlagille syndrome (ALGS) is a complex and rare autosomal dominant disorder that affects multiple systemic organs, including the liver, heart, kidneys, blood vessels, and eyes. However, as a rare disease, adult ALGS is still underrecognized clinically. The aim of this article is to review the research status and trends of adult ALGS worldwide in the existing literature.
methodsThe authors utilized the Web of Science Core Collection database to identify articles on adult ALGS published from the database inception to December 31, 2023. The authors used bibliometric methods to analyze authors, institutions, countries, journals, and references of 156 included articles.
resultsThe number of publications in this field has shown a volatile growth trend. The United States published the most articles and University of Pennsylvania is the leading institution in this area. The research on adult ALGS mainly focuses on molecular biology, genetics, health, nursing and clinical medicine. The keywords were "human jagged1," mutations" and "children". The keyword with the strongest citation burst is "children".
conclusionsOur study systematically summarizes the results of adult ALGS researches, describes and predicts research hotspots and trends on a global scale, which may be helpful for clinicians and researchers to improve their clinical understanding of this disease, and provide a valuable reference for future intensive investigation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.