ArticleParasites & vectors2025
Trichinella spiralis adult excretory-secretory antigen promotes peripheral regulatory T cell differentiation and attenuates experimental colitis via TGF-β-like mechanisms.
Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Trichinella spiralis serine proteinase enhances antibody-dependent cell-mediated (ADCC) killing of newborn larvae by driving M1 polarization via the NF-κB pathway.Parasite (Paris, France) · 2026Article
- Multimodal analysis reveals potential association of CDH13 with endothelial cells and its overexpression in hepatocellular carcinoma.European journal of medical research · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundTrichinella spiralis adult excretory-secretory antigen (TsAES) has been proposed as a potential immunomodulator capable of promoting naïve T cell differentiation into peripheral regulatory T cells (pTregs). This study aims to investigate the effects of TsAES on pTreg development and evaluate its role in alleviating dextran sulfate sodium (DSS)-induced acute colitis.
methodsColonic lamina propria mononuclear cells (LPMC) from Foxp3
resultsFlow cytometry analysis demonstrated that TsAES stimulation promoted LPMC differentiation into Tregs, leading to a significant increase in pTregs within the colonic lamina propria of TsAES-immunized Foxp3
conclusionsTsAES demonstrates tumor growth factor-beta-like activity, driving pTreg differentiation and suppressing DSS-induced colitis with IL-10 upregulation. These findings highlight a beneficial clinical effect of helminth-derived antigens on the immunomodulation and management of inflammatory bowel disease.
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