Evidence map›Paper›PMID 40597325›Full record

ArticleArthritis research & therapy2025

Risk factors affecting the vital prognosis in patients with rheumatoid arthritis after primary cervical spine surgery: a retrospective study.

Takafumi Kuramoto, Koji Sakuraba, Kazuhiro Kai, Kazumasa Terada, Nobuo Kobara, Hirofumi Bekki, Jun-Ichi Fukushi

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Article in Arthritis research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Takafumi KuramotoClinical Research Center, NHO Kyushu Medical Center, Jigyohama 1-8-1, Chuo-Ku, Fukuoka, 810-8563, Japan.
Koji SakurabaClinical Research Center, NHO Kyushu Medical Center, Jigyohama 1-8-1, Chuo-Ku, Fukuoka, 810-8563, Japan. sakurabaksy@yahoo.co.jp.
Kazuhiro KaiClinical Research Center, NHO Kyushu Medical Center, Jigyohama 1-8-1, Chuo-Ku, Fukuoka, 810-8563, Japan.
Kazumasa TeradaClinical Research Center, NHO Kyushu Medical Center, Jigyohama 1-8-1, Chuo-Ku, Fukuoka, 810-8563, Japan.
Nobuo KobaraDepartment of Orthopaedic Surgery and Rheumatology, NHO Kyushu Medical Center, Jigyohama 1-8-1, Chuo-Ku, Fukuoka, 810-8563, Japan.
Hirofumi BekkiClinical Research Center, NHO Kyushu Medical Center, Jigyohama 1-8-1, Chuo-Ku, Fukuoka, 810-8563, Japan.
Jun-Ichi FukushiClinical Research Center, NHO Kyushu Medical Center, Jigyohama 1-8-1, Chuo-Ku, Fukuoka, 810-8563, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe effect of biologics on cervical spine lesions (CSLs) and vital prognosis in patients with rheumatoid arthritis (RA) remains unclear. This study investigated the risk factors for a poor vital prognosis in patients with RA requiring primary cervical spine surgery for CSLs.

methodsWe retrospectively investigated 139 patients with RA who underwent primary cervical spine surgery between January 2001 and December 2020. The vital prognosis was calculated using the Kaplan-Meier method. Patient data were collected from medical records to analyse the risk factors for vital prognosis using univariate and multivariate Cox regression analyses.

resultsThe vital prognosis was 62.7% at 10 years according to the Kaplan-Meier method. In univariate analysis, advanced age, lower serum albumin levels, high-dose prednisolone administration, non-use of methotrexate, and subaxial subluxation (SAS) comorbidity were significantly associated with a high risk of mortality. In multivariate analysis, advanced age, lower serum albumin levels, high-dose prednisolone administration, and SAS comorbidity were identified as risk factors for a poor vital prognosis.

conclusionsSAS comorbidity, high-dose prednisolone administration, lower serum albumin levels, and advanced age exacerbate the vital prognosis in patients with RA requiring primary cervical spine surgery. Strict disease control aimed at preventing CSL progression to SAS by maintaining the nutritional status and without using steroids is necessary to improve the vital prognosis of patients with RA.

Indexed as

Arthritis, RheumatoidCervical VertebraeAdultAgedFemaleHumansMaleMiddle AgedPrednisolonePrognosisRetrospective StudiesRisk FactorsSerum AlbuminPrednisoloneSerum AlbuminCervical spine lesionPrednisoloneRheumatoid arthritisSubaxial subluxationVital prognosis

Identifiers

PMID40597325
PMCPMC12210445

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