Evidence map›Paper›PMID 40597291›Full record

Trial reportMalaria journal2025

Assessing the community-level impact of group antenatal care on uptake of intermittent preventive treatment for malaria in pregnancy in Atlantique Department, Benin, 2021-2023: a cluster randomized controlled trial.

Julie R Gutman, Faustin Onikpo, Manzidatou Alao, Julie Niemczura, Stephanie Suhowatsky, Julie Buekens, Marie Adeyemi, Katherine Wolf, Catherine Dentinger, Alexandre Binazon and 8 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Malaria journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Julie R GutmanMalaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Malaria Branch, Global Health Center, 1600 Clifton Rd. NE, Atlanta, GA, 30322, USA. fff2@cdc.gov.
Faustin OnikpoU.S. President's Malaria Initiative Impact Malaria Project, MCD Global Health, Cotonou, Benin.
Manzidatou AlaoU.S. President's Malaria Initiative Impact Malaria Project, MCD Global Health, Cotonou, Benin.
Julie NiemczuraU.S. President's Malaria Initiative Impact Malaria Project, MCD Global Health, Silver Spring, MD, USA.
Stephanie SuhowatskyU.S. President's Malaria Initiative Impact Malaria Project, Jhpiego, Baltimore, MD, USA.
Julie BuekensU.S. President's Malaria Initiative Impact Malaria Project, MCD Global Health, Silver Spring, MD, USA.
Marie AdeyemiU.S. President's Malaria Initiative Impact Malaria Project, MCD Global Health, Cotonou, Benin.
Katherine WolfU.S. President's Malaria Initiative Impact Malaria Project, Jhpiego, Baltimore, MD, USA.
Catherine DentingerMalaria Branch, U.S. President's Malaria Initiative, CDC, Atlanta, GA, USA.
Alexandre BinazonU.S. President's Malaria Initiative Impact Malaria Project, MCD Global Health, Cotonou, Benin.
Audrey S Eunice AmoussouU.S. President's Malaria Initiative Impact Malaria Project, MCD Global Health, Cotonou, Benin.
Odette Aimée AlihounouU.S. President's Malaria Initiative Impact Malaria Project, MCD Global Health, Cotonou, Benin.
Courtney EmersonMalaria Branch, U.S. President's Malaria Initiative, CDC, Atlanta, GA, USA.
Ahmed Saadani HassaniU.S. President's Malaria Initiative, CDC, Cotonou, Benin.
Houetohossou CamilleMinistry of Health, Cotonou, Benin.
Cyriaque D AffoukouMinistry of Health, Cotonou, Benin.
Peter J WinchU.S. President's Malaria Initiative Impact Malaria Project/Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Aurore Ogouyèmi-HountoUnité de Parasitologie/Faculté des Sciences de la Santé, Université d'Abomey Calavi, Cotonou, Benin. aurorefel@yahoo.fr.

Funding

USAID 7200AA18C00014
6 · The paper itself

Abstract

backgroundIn 2023, an estimated 36 million pregnancies occurred in malaria endemic sub-Saharan Africa, but only 44% received the WHO recommended ≥ 3 doses of intermittent preventive treatment (IPTp3). Group Antenatal Care (G-ANC) is a service delivery model associated with higher quality of and greater retention in ANC, in which pregnant women are enrolled into groups at their first ANC visit and subsequent care is provided in groups. A cluster-randomized controlled trial was conducted in Atlantique Department, Benin, to assess whether G-ANC improved ANC retention and IPTp3 uptake at community level.

methodsForty purposively selected health facilities (HF) were randomized 1:1 to control (individual ANC) or G-ANC. Cross-sectional household surveys to measure uptake of ANC and IPTp were conducted in each HF catchment area before and after implementation among randomly selected women who had given birth in the previous 12 months. Changes in coverage were assessed using a difference-in-difference approach, adjusting for HF clustering.

resultsAt baseline (N = 1259), coverage of at least 4 ANC visits (ANC4) and IPTp3 was 52.8% and 48.0%, respectively, in the intervention catchment, and 44.9% and 49.4% in the control catchment. Coverage of ANC4 improved in both arms by endline (N = 1280), to 56.7% in the intervention and 46.1% in the control, but the difference in the increase was not significant between arms (p = 0.51). Coverage of IPTp3 increased non-significantly (p = 0.26), to 53.2% (intervention) and 49.7% (control). Overall, only 140 (10.6%) surveyed women reported participating in G-ANC. Participation improved coverage of both ANC4 (65.0% vs 50.5%, p = 0.002; odds ratio (OR) 1.9, 95% CI 1.4-2.5) and IPTp3 (64.0 vs 50.6%, p = 0.004; OR = 1.8, 95% CI 1.2-2.6).

conclusionsG-ANC increased ANC attendance and IPTp3 uptake among women who participated, but participation was limited. Understanding and addressing the barriers to participation is critical if G-ANC is to be used more widely to increase IPTp coverage.

trial registrationPACTR202405487752509.

Indexed as

AntimalarialsMalariaPregnancy Complications, ParasiticPrenatal CareAdolescentAdultBeninCross-Sectional StudiesFemaleHumansPregnancyYoung AdultAntimalarialsAntenatal careBeninGroup ANCMalariaPregnancyPrevention

Identifiers

PMID40597291
PMCPMC12211219

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.