ArticleJournal of cannabis research2025
Orally consumed cannabinoids: the effect of carrier oil on acute tissue distribution in male C57BL/6 mice.
Article in Journal of cannabis research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Photoreceptor preservation by FAAH inhibition in a murine model of retinitis pigmentosa.Molecular neurobiology · 2026Article
- An Accurate Method Based on Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry for the Quantification of Five Cannabinoids in Juvenile and Adult Caenorhabditis elegans.Journal of separation science · 2026Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundFundamental gaps in knowledge exist in understanding the tissue distribution of cannabinoids, cannabidiol (CBD) and tetrahydrocannabinol (THC), following oral ingestion. CBD and THC are lipid-soluble and oral bioavailability is increased when combined with long-chain fatty acid carrier oils prior to oral ingestion. Oils with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) confer positive health benefits and have yet to be examined as a carrier oil for oral cannabinoid delivery thus, examination is warranted.
methodsThis study investigated the acute tissue distribution of cannabinoids in serum, adipose, brain, liver, heart, and muscle of male C57BL/6 mice at 1, 2, and 3 h (H) post oral ingestion. Mice were gavaged with CBD (5 mg/kg) and THC (1 mg/kg) combined with either sesame (SES), mixed EPA/DHA, or DHA enriched (DHA) oil as a carrier. With assistance of the Analytical Facility for Bioactive Molecules (Toronto, Canada), tissue concentration of cannabinoids was quantified using liquid chromatography with tandem mass spectrometry.
resultsSES oil resulted in a significantly greater concentration of CBD and THC (p < 0.05) across all tissues and times compared to the n-3 polyunsaturated fatty acid (PUFA) oils. The ratio of EPA:DHA in the carrier oils modestly affected distribution of cannabinoids to tissues, notably, DHA oil resulted in a greater concentration of CBD in the brain. Heart tissue had the highest concentration of CBD at 1 and 2H post-oral gavage, and adipose tissue had the highest concentration at 3H which was consistent across all three carrier oils.
conclusionsThis study profiled the greatest number of tissues to-date for the acute distribution of CBD and THC following oral consumption with a lipid carrier in mice which demonstrated a non-uniform distribution to tissues over time. SES oil proved to be far more effective as a carrier oil at delivering orally consumed cannabinoids to tissues compared to two different n-3 PUFA containing oils. Further developing our fundamental understanding of cannabinoid distribution across tissues following their consumption from foods and pharmaceuticals are necessary to establish specific pharmacokinetic profiles to aid oral dosing strategies and maximize the bioactive potential of cannabinoids.
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