ReviewChinese medicine2025
Natural phytochemical-based strategies for antibiofilm applications.
Review in Chinese medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed.
- Bioactive goldenseal (Hydrastis canadensis) fraction suppresses multidrug-resistant Pseudomonas aeruginosa in a rat burn wound model: oral and topical administration.Scientific reports · 2026Article
- Integrated in Vitro and in Silico Investigation of Antimicrobial, Anti-biofilm, and Quorum-Sensing Inhibitory Activities of Allium atroviolaceum Bulb Extract.Applied biochemistry and biotechnology · 2026Article
- Prevention and Treatment ofPathogens (Basel, Switzerland) · 2026Review
- Comparative Phytochemical Profiling and In Vitro Antibiofilm Activity of the Aerial and Underground Parts ofPlants (Basel, Switzerland) · 2026Article
- A bibliometric analysis of global research on plant-derived antimicrobials targeting Methicillin-resistant Staphylococcus aureus (2004-2024).European journal of microbiology & immunology · 2026Review
- Bacterial Biofilm and Titanium Implants: Mechanisms, Clinical Problems, and Surface Modification Strategies.Materials (Basel, Switzerland) · 2026Review
- Pentacyclic Triterpenoid Acids Inhibit the Expression of Quorum Sensing-Related Virulence Factors and the Formation of Biofilm inAntibiotics (Basel, Switzerland) · 2026Article
- Review
- Evaluation of Plant-Guided Strategies Against Clinical Multidrug-Resistant Pathogens: Preliminary Phytochemical Screening, Antioxidant Capacity, and Antibacterial/Antibiofilm Activity ofAntibiotics (Basel, Switzerland) · 2026Article
- Article
- Tackling Biofilm-Forming Pathogens: A Challenge to Overcome in the Fight Against Infectious Diseases.Pathogens (Basel, Switzerland) · 2026Review
- Phytochemical Profiling, Antioxidant, and Broad-Spectrum Antimicrobial Activities ofACS omega · 2026Article
- Bioinformatics-Driven, Plant-Based Antibiotic Research Against Quorum Sensing and Biofilm Formation inBiomolecules · 2026Review
- Antibacterial, antibiofilm, and metabolomic profiling of the novel freshwater fungi Longipedicellata megafusiformis and Wicklowia fusiformispora.Scientific reports · 2026Article
- Unveiling the antibacterial potential of green-synthesized silver chloride and silver chromium nanoparticles fromMicrobiology spectrum · 2026Article
- Fatty Acids as Prebiotics and Their Role in Antibiofilm Activity.Antibiotics (Basel, Switzerland) · 2026Review
- Coordination-based nanocomposite hydrogel promotes tissue regeneration under infection-compromised conditions.Regenerative biomaterials · 2026Article
- Biogenic Silver-Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus.PloS one · 2026Article
- Resistance breakers: a novel approach to tackle biofilm associated infections and antimicrobial resistance.Frontiers in microbiology · 2026Review
- A comprehensive review of emerging therapeutic strategies against methicillin-resistantFrontiers in microbiology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundBiofilms contribute to the persistence of infectious diseases, complicate the treatment of chronic infections and pose a significant global health threat. However, the effectiveness of antibacterial therapies is often limited by poor penetration of antibiotics, as well as the horizontal transfer of antibiotic resistance genes among bacteria. Phytochemicals remain a promising source for developing novel antibiofilm agents.
methodsA systematic search of literatures was conducted using PubMed, Web of Science, Google scholar, and CNKI, with keywords related to "phytochemicals", "natural products", "natural compounds", "alkaloids", "polyphenols", "terpenoids", "quinones", "nanomaterials", "biofilms", "biofilm formation", "biofilm inhibition", and "structure-activity relationship" focusing on studies published from 2014 to 2025.
resultsA total of 38 most extensively studied natural phytochemicals, including alkaloids, flavonoids (i.e., flavonols, flavanols, and chalcones), quinones, non-flavonoid polyphenols, terpenes and others, were systematically screened based on relevant articles from the past decade. Phytochemicals mainly work by targeting quorum sensing systems, reducing virulence factor production, preventing the initial adhesion and targeting the extracellular polymeric substances of biofilms. Well-designed phytochemical-based nanomaterials can enhance permeability, drug loading efficiency, target drug delivery and sustained drug release of phytochemicals, thereby increasing their antibiofilm efficacy.
conclusionPhytochemicals represent a promising therapeutic source for the elimination of bacterial biofilms and associated infections both in the form of molecules or nanomaterials. By synthesizing current progress and identifying future directions, phytochemical-based strategies may inspire innovative solutions and promote translational efforts in combating biofilm-associated challenges in clinical and environmental contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.