ArticleBMC medicine2025
Faecalibacterium prausnitzii promotes anti-PD-L1 efficacy in natural killer/T-cell lymphoma by enhancing antitumor immunity.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Metabolic-inflammatory index CTI identifies high-risk early-stage natural killer/T-cell lymphoma and informs a novel prognostic model.Biomarker research · 2026Article
- Decoding the cancer microbiome: multi-omics, AI, and translational opportunities.Genome biology · 2026Review
- Bibliometric and visual analysis: A comprehensive tracking of global research trends on ablation and tumor immune microenvironment from 2016 to 2025.Translational oncology · 2026Article
- Enterococcus hirae Y-HS Alleviates Ulcerative Colitis by Activating PXR/Nrf2-mediated Metabolic-immune Crosstalk.Probiotics and antimicrobial proteins · 2026Article
- Microbial reprogramming of immunogenic cell death: a new paradigm in tumor immunotherapy.Cancer biology & medicine · 2026Review
- Serum free fatty acid promotes tumor progression and predicts golidocitinib sensitivity in peripheral T-cell lymphoma.Blood advances · 2026Article
- Targeting the gut microbiota-metabolite-immune axis in cancer immunotherapy: mechanistic interplay, therapeutic strategies, and translational applications-a narrative review.Translational cancer research · 2026Review
- Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice.NPJ Parkinson's disease · 2026Article
- Article
- Gut microbiota in esophageal cancer: mechanisms, clinical implications, and therapeutic potential.Frontiers in microbiology · 2026Review
- Plasma untargeted metabolomics reveals the metabolic landscape of NKTCL and aids in liquid biopsy for disease detection.European journal of medical research · 2025Article
- Prebiotic Structural Diversity Shapes Gut Microbial Diversity, Community Composition, and Metabolic Activity In Vitro.Foods (Basel, Switzerland) · 2025Article
- PD-1/PD-L1 Cancer Immunotherapeutics Reshape Tumor Microenvironment - Clinical Evidence and Molecular Mechanisms for AI-based Precision Medicine.Clinical reviews in allergy & immunology · 2025Review
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8 authors.
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Abstract
backgroundNatural killer/T-cell lymphoma (NKTCL) is a highly aggressive subtype of lymphoma characterized by a poor prognosis. While immune checkpoint blockade (ICB) therapy has emerged as an effective treatment modality for various cancers, its efficacy among individuals is inconsistent and remains suboptimal for the majority of NKTCL patients. Faecalibacterium prausnitzii, recognized as a next-generation probiotic with immunomodulatory capabilities, has not yet been fully explored for its potential to influence the outcomes of ICB therapy.
methodsWe established syngeneic tumor-bearing mouse models of NKTCL and treated the mice with an anti-PD-L1 monoclonal antibody (mAb) and F. prausnitzii. Metabolomics analysis was performed to quantify butyrate concentrations in fecal, plasma, and tumor samples from the mice. Furthermore, we used flow cytometry, multiplex immunohistochemistry, and enzyme-linked immunosorbent assays to assess the effects of butyrate supplementation on antitumor immune responses in mice receiving anti-PD-L1 therapy. Additionally, an antibiotic-pretreated mouse model was utilized to further investigate the influence of F. prausnitzii on the efficacy of ICB therapy.
resultsThe combination of F. prausnitzii and an anti-PD-L1 mAb effectively inhibited tumor growth, primarily through the action of its metabolite butyrate. Notably, F. prausnitzii-derived butyrate played a crucial role in enhancing the efficacy of ICB therapy by augmenting antitumor immune responses, as evidenced by reduced PD-L1 expression and increased levels of cytotoxic CD8+ T cells within the tumor microenvironment. Moreover, prior administration of antibiotics significantly compromised the efficacy of the anti-PD-L1 mAb. However, supplementation with F. prausnitzii mitigated the negative effects of antibiotics and restored the altered gut microbiota in tumor-bearing mice.
conclusionsThis study highlights the potential of F. prausnitzii in augmenting ICB therapy and presents a novel gut probiotic-centered therapeutic strategy for the treatment of NKTCL.
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