Evidence map›Paper›PMID 40597168›Full record

SynthesisBMC medical education2025

Substance use and academic performance among university students: systematic review and meta-analysis.

Giampiera Bulfone, Fabio Ingravalle, Francesco Scerbo, Rocco Mazzotta, Ilaria Simonelli, Alessandra Pancaldi, Stefano Ungaro, Michela Cocco, Ercole Vellone, Rosaria Alvaro and 2 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC medical education, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Motivation Profiles Towards Academic Reading, Substance-Related and Problematic Behaviors in Future Teachers.European journal of investigation in health, psychology and education · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giampiera Bulfone *Department of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia" (DGFI), University of Catania, Catania, Italy.
Fabio IngravalleDoctoral Degree in Nursing Sciences and Public Health, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Francesco Scerbo *Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Rocco MazzottaDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. Rocco.mazzotta@uniroma2.it.
Ilaria SimonelliDoctoral Degree in Nursing Sciences and Public Health, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Alessandra PancaldiDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Stefano UngaroDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Michela CoccoDoctoral Degree in Nursing Sciences and Public Health, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Ercole VelloneDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Rosaria AlvaroDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Antonio VinciDoctoral Degree in Nursing Sciences and Public Health, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Massimo MauriciDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy. maurici@med.uniroma2.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubstance use is a widespread concern among young adults and is particularly significant among college students. Substance use in this population is associated with several academic, physical, mental, and social difficulties. This systematic review and metanalysis explores whether there is an effect of the legal and illegal substance and alcohol consumption behaviors on academic achievement among university students.

methodsThe databases searched were MEDLINE, CINHAL, Scopus, ERIC, and PROSPERO, updated in January 2025. The risk of bias was assessed using the Edwards score. We used a random-effects model. The protocol of this review was registered in the Open Science Framework.

resultsThe systematic review included 21 studies, while the meta-analysis included four studies. In a sample of 1,219 subjects in the control group and 350 legal and illegal substances consumers, there is a negative and significant association of substances consumption on academic achievement [SMD = - 0.61 (95% CI - 0.84 to - 0.38; p = 0.008). In a subgroup analysis, a sample of 2,479 subjects in the control group and 7,134 alcohol consumers, there is a non-statistically significative association of alcohol consumption on academic achievement [SMD = - 0.24 (95% CI -0.51 to 0.04; p = 0.073).

conclusionsDespite the limitations of this study, this systematic review provides quantitative evidence on the relationship between legal and illegal use of substances among university students and academic achievement. Specifically, we found a significant medium association of substance use in general and a small effect for alcohol consumption on academic achievement. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Academic PerformanceAlcohol DrinkingStudentsSubstance-Related DisordersHumansUniversitiesYoung AdultAcademic achievementAlcohol drinkingSubstances use disordersUniversity student

Identifiers

PMID40597168
PMCPMC12211851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.